LGD-4033 was safe, had favorable pharmacokinetic profile, and increased lean body mass even during this short period without change in prostate-specific antigen. Longer randomized trials should evaluate its efficacy in improving physical function and health outcomes in select populations.

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Dengue fever (DF) is a national health problem in Pakistan. It has become endemic in Lahore after its recent reemergence in 2016. This study investigates the impacts of climatic factors (temperature and rainfall) on DF transmission in the district of Lahore through statistical approaches. Initially, the climatic variability was explored using a time series analysis on climatic factors from 1970 to 2012. Furthermore, ordinary and multiple linear regression analyses were used to measure the simulating effect of climatic factors on dengue incidence from 2007 to 2012. The time series analysis revealed significant annual and monthly variability in climatic factors, which shaped a dengue-supporting environment. It also showed a positive temporal relationship between climatic factors and DF. Moreover, the regression analyses revealed a substantial monthly relationship between climatic factors and dengue incidence. The ordinary linear regression of rainfall versus dengue showed monthly R2 = 34.2%, whereas temperature versus dengue presented R2 = 38.0%. The multiple regression analysis showed a monthly significance of R2 = 44.6%. Consequently, our study shows a substantial synergism between dengue and climatic factors in Lahore. The present study could help in unveiling new ways for health prediction modeling of dengue and might be applicable in other subtropical and temperate climates.

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