Background Road traffic accidents (RTAs) have become a major issue in today's world. They have caused the loss of more than a million lives in the last decade and are substantially increasing every day. Injuries due to RTAs can cause significant morbidity and mortality. These injuries can be sorted by the type, body region, gender, and age group. We aimed to highlight the frequency and nature of road traffic injuries (RTIs) according to these variables in Ha'il, the Kingdom of Saudi Arabia. Methods A retrospective study was conducted in King Khalid Hospital, Ha'il. Data on the cases of RTIs were collected, which presented to the hospital emergency department from January 1, 2016, to December 31, 2017. Data analysis was then performed using IBM Statistical Package for the Social Sciences 17.0 (SPSS, IBM, NY, USA). Frequencies were calculated using descriptive statistics, and graphs were generated. Results A total of 10,855 patients with RTIs were encountered at the hospital emergency department. Out of these, 8035 patients were males (74.02%) while 2820 were females (25.97%). Fractures of one or more sites were the most common type of injury, encountered in 5173 patients (47.66%). Lacerations occurred in 3487 patients (32.12%). Crush injuries were encountered in 1190 patients (10.96%) while penetrating injuries occurred in 844 patients (7.78%). Abdominal and pelvic visceral injuries were present in 103 patients (0.95%) while thoracic visceral injuries were present in 39 patients (0.36%). Amputations occurred in 19 patients (0.18%). Conclusion Our study highlights the frequency and nature of road traffic injuries that present in the emergency department. As suggested by the high frequency of specific types of injuries, special training should be provided to healthcare professionals to address and treat fractures, head and neck injuries, and serious lacerations effectively.

IntroductionMedical students choose to pursue their careers based on multiple internal and external factors. These factors, in turn, not only affect their personal future but the overall status of the health care system of their country. A recent decline in the interest of medical students towards the surgical career is being observed and, therefore, the factors influencing their choice need to be evaluated. We aimed to identify these factors in medical students of a public sector university of Karachi.MethodsA cross-sectional study was conducted at Dow Medical College from April 2018 to May 2018. A pre-tested questionnaire was administered to a sample of 250 students. Besides sociodemographic factors, the choice of career was identified and the factors that influenced it were assessed. Students' opinions were collected using a Likert scale. Data were entered and analyzed using the IBM Statistical Package for the Social Sciences 23.0 (IBM, NY, USA). Frequencies were calculated for individual variables. The chi-square test was used to measure statistical differences between categorical variables and a p-value of <0.05 was considered to be significant.ResultsIn this study, 224 out of 250 questionnaires were returned with complete data, yielding a response rate of 89.6%. We found that 48.2% of students reported a desire to pursue a career in surgery. Students whose fathers were more qualified and belonged to the field of health care were more likely to pick a surgical career (p-value of 0.034 and 0.039, respectively). Students who were willing to pursue a path in surgery more often thought that the social standing of surgeons had its importance (p=0.037). These students also agreed that high salary has a role to play in affecting the choice of career (p=0.023). The most common factors that encouraged students for the choice of a surgical career included the practical implication of skills (57.4%) followed by an academic interest in the field (53.7%), and high income (42.6%). The most common discouraging factors included lifestyle and long working hours (56.9%), followed by less academic interest (31%).ConclusionOur study provides a valuable insight into the factors that influence the choice of medical students for pursuing a career in surgery. We also identified the factors that demotivated them from doing so. In our opinion, better incorporation of surgery into the curriculum, proper attention given to students during their surgical rotation and restructuring of the surgical training program are some of the ways that may improve the interest of students in the field of surgery.

Objective For more than a century since its introduction, mercury sphygmomanometer (HgS) had been the mainstay for office measurement of blood pressure (BP). In light of the environmental and health hazards associated with mercury, there is a need to replace it with mercury-free alternatives all over the world. We aimed to validate the widely used aneroid sphygmomanometer (AnS) by comparing its BP readings against BP readings taken with an HgS. Methods We compared the BP readings using AnS vs. HgS on a sample of 300 patients of 18 years or older age admitted to a tertiary care hospital in Karachi, Pakistan. Results The differences between mean HgS and AnS BP readings were found to be statistically significant (P-value <0.01). The mean systolic blood pressure (SBP) readings of the two devices were still significantly correlated (r = 0.989; P < 0.01). Similarly, the mean diastolic blood pressure (DBP) readings were also significantly correlated (r = 0.988; P < 0.01). The aneroid device identified a higher proportion of hypertensive participants compared to the mercury device. Conclusion The difference in the two devices used was found to be significant; however, the readings were correlated with each other. The AnS significantly overestimated BP readings, thereby identifying a higher proportion of hypertensives as compared to the HgS. There is a considerable room for improvement in the accuracy of the AnS, only then an accurate and a well-calibrated AnS could provide an acceptable alternative to the use of the HgS.

Background X-ray imaging is a common procedure performed on a regular basis for diagnostic purposes all over the world. The use of X-rays is increasing rapidly with the introduction of new radiation-oriented therapeutic practices. Although it carries significant diagnostic benefits, extensive exposure to X-ray imaging has been shown to be associated with multiple dose-dependent health risks. Awareness and knowledge among patients regarding the effects of X-ray imaging, therefore, becomes important. Through this study, we aimed to assess the knowledge and awareness of the hazards of X-ray imaging among different groups of patients visiting two of the public sector tertiary hospitals in Karachi, Pakistan. We also aimed to evaluate the necessary safety measures undertaken during X-ray imaging in these hospitals, and the perception of patients regarding the importance of these measures. Materials and methods A cross-sectional study was conducted in October and November 2018 at two well-known public sector tertiary care hospitals, Dr. Ruth KM Pfau Civil Hospital, Karachi and Jinnah Postgraduate Medical Centre, Karachi. A non-probability convenience sampling technique was adapted to recruit 200 participants for the study. A pretested questionnaire was used to assess the knowledge of radiation among patients and their perception regarding the necessary safety measures required to be undertaken during the X-ray imaging procedure. Data were entered and analyzed using the IBM Statistical Package for the Social Sciences 17.0 (IBM Corp., New York, USA). Frequencies were calculated for individual variables. Chi-square test was employed to measure the relationship between categorical variables. A p-value of <0.05 was considered to be significant. Results Out of 200 participants, 58% knew what radiation was, 42% did not. The relationship between the level of education of patients and the awareness of the term ‘radiation’ was found to be statistically significant (p-value = 0.003). Television was the most common source of information (65.5%). One participant (0.5%) thought that it was possible for X-ray imaging to cause cancer. Similarly, only one participant (0.5%) thought that it could cause decreased fertility, five participants (2.5%) thought it could cause burns, seven (3.5%) thought it could cause cataract, and 20 (10%) were of the view that anemia could be caused. The majority of the participants (80.5%) thought that a lead sheet was important during the X-ray procedure for safety and protection. Most participants (71.5%) said that they were never provided with any such lead sheets. When asked if the participants requested for a lead sheet if not provided, the majority (71%) denied requesting for it. On analyzing, we found that a higher percentage of uneducated participants denied requesting a sheet compared to the educated ones. The relationship between the level of education and the choice of requesting for a lead sheet was found to be statistically...

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Objective: To determine the efficacy of the first triple CFTR protein modulators in children and adolescents with cystic fibrosis. Methods: Systematic review and meta-analysis were conducted, following PRISMA guidelines. The following databases were searched extensively: PubMed/Medline, Clinical trials.gov, Google Scholar, Scopus, Embase, and Europe PMC using the keywords: “Ivacaftor,” “Elexacaftor,” “Tezacaftor,” VX_661”, VX_770”, “VX_445”, “cystic fibrosis”. A total of ten randomized clinical trials were included in our analysis. Primary outcomes included: Absolute change in predicted FEV1 from baseline, Absolute change in sweat chloride test from baseline, Absolute change in BMI from baseline, Absolute change in CF-QR from baseline, and Adverse Events. Results: Among primary findings, significant absolute change in predictive FEV1 from baseline through 4 weeks favoured the triple CFTR protein modulators. [MD=11.80,95%CI=8.47_15.12, p value=<0.00001]; as well as CF_QR score [MD=0.00,95%CI=-2.50_2.50, p value=1.00], and BMI kg/m² change [MD=16.90,95%CI=12.73_21.06, p value=<0.00001]. No significant change was noted for CFTR channels activity in the treatment group when compared to placebo or VX_770/VX_661 [MD= -12.57,95%CI=-94.46_69.32, p value=0.76]. Conclusion: In children aged ≥ 6 y old and adolescents with F508del_CFTR mutation, Elexacaftor–Tezacaftor–Ivacaftor tend to be more effective than first-generation therapy, demonstrating promising results by exhibiting significant improvement in lung function, body weight, and respiratory-related quality of life.

The COVID-19 pandemic has affected 245,373,039 people globally with a death toll bearing 4,979,421 deaths to date [1]. It can be a cause of life-threatening metabolic acidosis that merits discussion [2]. Approximately 79.7% COVID affected individuals suffer acid-base disproportion [2]. According to a study, 2.8% of this total percentage is attributed to metabolic acidosis with 100% mortality at the end of follow up [2]. Various risk factors predispose a patient with COVID-19 to metabolic acidosis. SARS-CoV-2 infection is associated with grievous dysregulated inflammation (cytokine storm) involving the lungs [3]. With the engagement of the lung parenchyma, hypoxemia ensues, which increases the risk of fatal metabolic acidosis. Not to forget the role of sepsis in hypoperfusion, eventually inflicting metabolic acidosis. SARS-CoV-2 can directly or via sepsis trigger acute kidney injury giving rise to secondary metabolic acidosis in infected patients. Affected patients are at risk of acute liver failure due to the direct involvement of the liver during active infection which is another cause. Furthermore, in patients with diabetes mellitus who suffer from COVID-19, the use of corticosteroids to treat the infection is a potent inducer of diabetic ketoacidosis that predisposes to metabolic acidosis.

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