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Background: Epithelial-mesenchymal transition (EMT) is an important program in tumor metastasis. Results: SMAR1 inhibits EMT by up-regulating E-cadherin in a dual manner via repression of Slug transcription and inhibition of E-cadherin degradation. Conclusion: SMAR1 functions as a critical protein in regulating EMT. Significance: This study provides a potential mechanism for the contribution of SMAR1 in inhibiting breast cancer metastasis.

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The detailed molecular mechanism of transferrin-tagged thymoquinone nanoparticle mediated apoptotic induction in non-small cell lung carcinoma showing the involvement of p53 dependent synergistic activation of miR-34a and miR-16 in the pathway.

Cu electroplating was carried out using a pure ethaline melt, a 1:2 ratio of choline chloride and ethylene glycol, at room temperature by potentiostatic and galvanostatic methods. Hydrated cupric chloride was added to the pure ethaline melt. Polarisation data for cupric ion reduction to copper was collected using an RDE to determine where metal deposition was feasible. Smooth Cu deposits were obtained at -4.7×10-3A/cm2 using 0.2M CuCl2·2H2O at 25°C at a current efficiency of (95±5)% at a rotation speed of 700rpm. XRD analysis of the deposit showed a polycrystalline face centred cubic structure with (111) texture. The crystalline size was 66±10nm with some internal strain. EDX analysis showed the presence of carbon and chlorine with copper in the deposit, which was due to the break-down of the DES. Several deposition processes were carried out from a single bath to examine bath stability. The bath was found to be stable when a soluble anode was employed, and became unstable when an insoluble anode was used due to other reactions proceeding at the cathode

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Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual miRNA loading, efficient delivery and significantly inhibited tumor growth as well as retarded metastasis in triple-negative breast cancer.