Aim of research: to analyze the dental status of children with the teeth formation disorders on the background of the digestive diseases (DD). Object of research – the change of the teeth hard tissues and periodontal tissues, subject of research – clinical characteristics of the status of teeth hard tissues and periodontal ones. Results of research: in children with chronological enamel hypoplasia (CEH) and molar-incisor hypomineralization (MIH) on the background of digestive diseases (Class ICD-10, К00-К93: “Gastritis and duodenitis” (К29), “Cholecystitis” (К81), “Other bile-excreting diseases” (К83)) was fixed the high and very high intensity of the dental caries, respectively. Caries as CEH and MIH complication was diagnosed in 55,81 % and 42,85 % of examined, respectively. In children with CEH and MIH on the background of digestive organ diseases was diagnosed the middle severity of gingivitis РМА, Papillary, Marginal, Alveolar Indices): 29,13±8,87 % and 25,24±8,97 %, respectively. The rate of persons with the healthy periodontal tissues according to CPI (Community Periodontal Index) was 21,42±21,91 % in children with CEH and 7,14±13,11 % in examined with MIH. In examined with CEH and MIH was fixed the satisfactory hygiene of the oral cavity according to Green-Vermillion index (OHI – Oral Hygiene Index). Conclusion: children with teeth hard tissues formation disorders on the background of digestive diseases need the dispensary observation and course of the therapeutic and prophylactic arrangements for preventing the possible complications (caries, gingivitis, periodontitis).
Objective of research. To analyze features of stomatological status indexes, relative length of telomeres and phenotype of immunocompetent cells of peripheral blood in children with chronological enamel hypoplasia – residents of Ukrainian territories, contaminated with radionuclides after the Chornobyl NPP accident. Materials and methods. The object of research is chronological enamel hypoplasia (CEH) of permanent teeth, and lymphocytes of peripheral blood (PB). The subject of research is the state of oral cavity hygiene, caries intensity, gingivitis severity degree, relative telomere length (RTL), and phenotype of immunocompetent cells (ICC) of peripheral blood (PB). Methods of the research: stomatological, immunological (flow cytofluorometry), molecular genetic (fluorescence in situ hybridization-flow cytometry – flow-FISH), statistical. Results. Two types of the analysis of the stomatologic status, RTL and phenotype of PB ICC were carried out: the first is the comparison of indexes of the combined group of children with anamnesis complicated by radiation (group No. 1 with CEH + group No. 2 without CEH) comparing with the control group No. 3; the second is the analysis of indeces of the group No. 1 comparing with the same markers in children of the groups No. 2 and No. 3. The first stage of the analysis shows thesignificant worsening of oral hygien indices , high DMFTand DMFS in children with permanent dentition, higher degree of gums inflamation and moresignificant RTL shortening in children of the combined group (No. 1 + No. 2) comparing with the control. Changes of the same character, but more expressed observed during the another analysis concerning the children with anamnesis complicated by radiation and CEH comparing with the control. Reliable changes in the content of PB ICC subpopulations in the examined children of all groups were not identified. Conclusions. 1. Inchildren with CEH, complicated by ionizing radiation (IR) influence in low doses diapason the highest degree of stomatological status disorders comparing with the examined reference and control groups was determined: unsatisfactory and poor oral cavity hygiene according to OHI-S (1.76±0.41, р˂0.0001 and р˂0.0001, respectively) and Silness-Loe index (1.73±0.45, р˂0.0001 and р˂0.0001, respectively); very high intensity of dental caries ((DMFT=7.0±2.29, р=0.003and р˂0.0001; DMFS=8.74±2.58, р=0.0004 and р˂0.0001, respectively); mean degree of gingivitis severity (РМА 47.55±14.27 %, р˂0.0001 and р˂0.0001, respectively). 2. At CEH, which occurs due to the complex of negative factors during first years of life, including IR in residents of territories with effective doses more than 1.0 mSv/year, reliable shortening of relative telomeres length of PB lymphocytes comparing with the control group (15.17±3.20, р=0.0002) was found. Reliable differences in the content of peripheral blood immunocompetent cells when compared the examined groups were not identified. 3. Results of indices of the groups No. 1, No. 2 and No. 3 comparison are agreed with the data, obtained in result of dispersive analysis that allowed to separate the most informative indices concerning stomatological examination of children: OHI-S index (F=34.92; р˂0.001); Silness-Loe index (F=27.01; р˂0.001); dft+DMFT (F=82.23; р˂0.001); dfs+DMFS (F=49.41; р˂0.001); DMFT (F=13.94; р˂0.001); DMFS(F=19.41; р˂0.001); РМА (F=41.25; р˂0.001); RTL (F=7.53; р=0.001).
Aim of research. To raise the effectiveness of anticarious properties of oral cavity in children with enamel hypoplasia by introduction of the complex of arrangements, directed on optimization of the oral cavity hygiene, level of secretory immunoglobulin А (sIgA) and the content of mineral components of oral liquid (calcium and orthophosphates). Materials and methods. Object of research – enamel hypoplasia of the permanent teeth. Subject of research – hygienic status of the oral cavity, level of general calcium, orthophosphates, sIgA in the oral liquid. Methods of research: vital coloration of enamel, transillumination, photometric, immune-enzyme method, indices of hygienic status of the oral cavity (Green–Vermillion (1964) index, Silness–Loe (1964, 1967) index). There was carried out an assessment of hygienic status of the oral cavity, determination of the level of calcium, orthophosphates and sIgA in the oral liquid of 45 children, 6–14 years old (group № 1 – 21 persons, group № 2 – 24 persons). Group №1 – children, who underwent the complex of prophylactic arrangements that included recommendations as to the choice of means and subjects for the oral cavity care and teaching the standard method of teeth brushing. Group № 2 – children, who additionally used remineralizing cream on the water base with casein phosphopeptide – amorphous calcium phosphate (СРР-АСР) (Certificate on the state registration №10014/2010 of 03.12.2010). Results. Hygienic status of the oral cavity of children from the both groups was assessed as “unsatisfactory” one according to Green–Vermillion index and as “bad” one according to Silness–Loe index. After prophylactic arrangements the oral cavity status was improved in children of the group № 1: Green–Vermillion (p=0,0013) and Silness–Loe (p=0,0002) indices essentially decreased. In children of the group №2 after prophylactic arrangements hygienic status of the oral cavity was improved more essentially: Green–Vermillion (p=0,0002) and Silness–Loe (p=0,0002) indices reliably decreased. Prescription of remineralizing cream to the children of group № 2 reliably raised the content of calcium (р=0,0051) and sIgA in the oral liquid (р=0,001). Orthophosphates level did not essentially change in both groups. Conclusions. Introduction of the complex of prophylactic arrangements with additional use of remineralizing preparation favored the more essential improvement of the oral cavity hygiene, raise of calcium and sIgA in the oral liquid.
Aim of research: To increase the resistance of teeth enamel in children with disorders of their formation by introduction of the complex of prophylactic arrangements using remineralizing preparation. Materials and methods. The object of research is the zones of injured enamel (on the background of hypoplasia) of permanent teeth. The subject is the level of general calcium and orthophosphates in acid biopsy materials of injured teeth enamel. Methods of research: the vital coloration of enamel, transillumination, acid biopsy of enamel, photometric, statistic. There was carried out the determination of level of calcium and orthophosphates in acid biopsy materials of injured enamel in 45 children, 6–12 years old with enamel hypoplasia. The group № 1 (21 persons) – children who underwent the complex of prophylactic arrangements that included recommendations as to the choice of means and subjects for oral cavity care and teaching the standard method of teeth brushing. The group № 2 (24 persons) – children, who additionally used remineralyzing cream on the water base with casein phosphopeptide – amorphous calcium phosphate (СРР-АСР) (Certificate on the state registration №10014/2010 of 03.12.2010). Results. In children with chronologic enamel hypoplasia was established the low level of calcium and orthophosphates in acid biopsy materials of injured enamel. Calcium/phosphorus (Са/Р) coefficient in examined groups № 1 and № 2 was 1,26±1,14 and 1,19±0,56, respectively. The high effectiveness of the offered complex of prophylactic arrangements (teaching the hygienic habits – group №1, additional use of remineralizing cream – group № 2) is proved by the growth of macroelements content in acid biopsy materials of injured enamel in examined children. The holding of prophylactic arrangements in children of the group № 2 using remineralizing cream, favored the more essential growth of level of calcium and orthophosphates in biopsy materials comparing with group of children № 1 (р=0,002 and р=0,03, respectively), and also reliably increased Са/Р coefficient (р=0,0005). Conclusions. Introduction of complex of prophylactic arrangements using remineralizing preparation in children with disorders of teeth formation favored the rise of enamel resistance as a result of growth of the level of calcium and orthophosphates in its mineral component.
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