Cocoa powder considered a high rich source of polyphenols so it reduce the lipid profile in blood and the risk of cardiovascular disease. The present investigation aimed to assess the biochemical and nutritional properties on cocoa powder and its effect on blood lipids in rats. Twenty Four male albino rats Sprague Dawley Strain weighing (150±10 g.) were used in the experiment. All rats were fed on basal diet (one week) for adaptation. Then randomly divided into two main groups as following : The first main group include: (G1) fed on basal diet as a negative control group (-ve). The second main group was fed on high fat diet (HFD) for (4 weeks) to induce hyperlipidemia. Then, rats were divided into three groups as following: (G2) fed on high fat diet as a positive control group (+ve), (G3,G4), were fed high fat diet supplemented with cocoa powder (5%, 10% respectively). The results indicated a significant decrease in BW, FI, and FER in rats fed with HFD diet + cocoa powder nearly from negative control group (-ve). (HFD) rats showed a significant increase in serum total cholesterol, triglycerids, LDL-c, VLDL-c, compared to negative control group(-ve). On the other hand, (HFD) rats showed a significant decrease in serum high-density lipoproteins (HDL-c) compared to normal control group (-ve). While cocoa powder improve lipids profile and protective from cardiovascular risk .
Cocoa powder considered a high rich source of polyphenols so it reduce the lipid profile in blood and the risk of cardiovascular disease. The present investigation aimed to assess the biochemical and nutritional properties on cocoa powder and its effect on blood lipids in rats. Twenty Four male albino rats Sprague Dawley Strain weighing (150±10 gm.) used in experiment. All rats were fed on basal diet (one week) for adaptation. Then randomly divided into two main groups as following : The first main group include: (G1) fed on basal diet as a control negative group (-ve). The second main group was fed on high fat diet (HFD) for (4weeks) to induce hyperlipidemia. Then, rats were divided into three groups as following: (G2) fed on high fat diet as a positive control group (+ve), (G3,G4), were fed high fat diet supplemented with cocoa powder (5%, !0% respectively). The results indicated a significant decrease in BW, FI, and FER in rats fed with basil diet + cocoa powder nearly from negative control group (-ve). (HFD) rats showed a significant increase in serum total cholesterol, triglycerids, LDL-c, VLDL-c, compared to negative control group(-ve). On the other hand, (HFD) rats showed a significant decrease in serum high-density lipoproteins (HDL-c) compared to normal control group (-ve). While cocoa powder improve lipids profile and protective from cardiovascular risk .
yslipidemia is a major contributor to atherosclerotic cardiovascular disease. Recently, World Health Organization (WHO) reported that cardiovascular diseases (CVD) account for 46% of ever all mortality in Egypt. So that; the present study investigated, the protective effect of nettle and olive leaves on hyperlipidemia in experimental rats. Thirty six male albino rats weighing 130 ± 20 g used in this study and divided into equal six groups ( 6 rats each),the first kept as anegative control group (-ve) received basal diet throughout the experiment period, while the second was the (+ve) control group which fed on hyperlipidemic diet for four weeks, while the four others groups given hyperlipidemic diet supplemented with nettle leaves (5%) ,( 10 %) and olive leaves(5 %), (10%) respectively for four weeks (astreatment groups ) .The chemical composition and phenolic compounds of both leaves were done . At the end of the experiment, biological data were calculated; blood samples were taken to biochemical analysis. In addition, histopathological examination was done. The results revealed that hyperlipidemic diet in the (+ve) control group increased body weight gain ,relative organ weight, serum lipid profile, Malondialdhyde (MDA), liver enzymes and serum glucose, decreased in serum HDL-C, serum Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) . All treated groups with two leaves showed improvement previously parameters compared with positive control group. In conclusion, the consumption of nettle and olive leaves could be used for improving lipid profile, liver function and protect from hyperlipidemia in experimental rats.
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