The consumption of foods polluted with different foodborne pathogens such as fungus, viruses, and bacteria is considered a serious cause of foodborne disease in both humans and animals. Multidrug-resistant foodborne pathogens (MRFP) cause morbidity, death, and substantial economic loss, as well as prolonged hospitalization. This study reports on the use of aqueous Rumex leaf extract (ARLE) in the synthesis of silver nanoparticles (ARLE-AgNPs) with versatile biological activities. The synthesized ARLE-AgNPs had spherical shapes with smooth surfaces and an average hydrodynamic size of 27 nm. ARLE-AgNPs inhibited the growth of Escherichia coli ATCC25721, Pseudomonas aeruginosa ATCC27843, Streptococcus gordonii ATCC49716, Enterococcus faecalis ATCC700813, and Staphylococcus aureus ATCC4342. The ARLE-AgNPs were more active against Escherichia coli ATCC25721 than other harmful bacterial strains (26 ± 3 mm). The zone of inhibition for antibacterial activity ranged between 18 ± 3 mm and 26 ± 3 mm in diameter. The nanoparticles’ MIC values varied from 5.19 µg/mL to 61 µg/mL, while their MBC values ranged from 46 µg/mL to 119 µg/mL. The nanoparticles that were created had antioxidant potential. The cytotoxic activity was tested using normal fibroblast cell lines (L-929), and the enhanced IC50 value (764.3 ± 3.9 g/mL) demonstrated good biological compatibility. These nanoparticles could be evolved into new antibacterial compounds for MRFP prevention.
yslipidemia is a major contributor to atherosclerotic cardiovascular disease. Recently, World Health Organization (WHO) reported that cardiovascular diseases (CVD) account for 46% of ever all mortality in Egypt. So that; the present study investigated, the protective effect of nettle and olive leaves on hyperlipidemia in experimental rats. Thirty six male albino rats weighing 130 ± 20 g used in this study and divided into equal six groups ( 6 rats each),the first kept as anegative control group (-ve) received basal diet throughout the experiment period, while the second was the (+ve) control group which fed on hyperlipidemic diet for four weeks, while the four others groups given hyperlipidemic diet supplemented with nettle leaves (5%) ,( 10 %) and olive leaves(5 %), (10%) respectively for four weeks (astreatment groups ) .The chemical composition and phenolic compounds of both leaves were done . At the end of the experiment, biological data were calculated; blood samples were taken to biochemical analysis. In addition, histopathological examination was done. The results revealed that hyperlipidemic diet in the (+ve) control group increased body weight gain ,relative organ weight, serum lipid profile, Malondialdhyde (MDA), liver enzymes and serum glucose, decreased in serum HDL-C, serum Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) . All treated groups with two leaves showed improvement previously parameters compared with positive control group. In conclusion, the consumption of nettle and olive leaves could be used for improving lipid profile, liver function and protect from hyperlipidemia in experimental rats.
H YPERLIPIDEMIA is one of the most public health problems in the modern era that increase the risk of several comorbidities such as cardiovascular disease and cancer. So, this study was investigated the effect of pomegranate seeds and wheat germ oils as protective agents against hyperlipidemia in rats. A total of 36 male albino rats weighing 120-130 g. were used. Rats were divided into six equal groups; the first group kept as a control negative group and was fed on basal diet, while the second group was fed high fat diet for 4 weeks as a positive control group .The third and fourth groups were fed on high fat diet and given oral administration of pomegranate seed oil (0.4) and (0.8) mL/kg. B. Wt. for 4 weeks as a protective agent, respectively. The fifth and sixth groups were fed on high fat diet and given oral administration of wheat germ oil (1) and (1.5) mL /kg. B. Wt. for 4 weeks as protective agents, respectively. At the end of the experimental period (4 weeks), the feed intake (FI), body weight gain (gm.), feed efficiency ratio (FER) and relative liver weight were calculated. Serum liver enzymes (ALT, AST and ALP), total cholesterol, triglycerides, HDLc and LDLc and histopathological changes of heart were examined. Total antioxidant and total polyphenols were performed in pomegranate seeds and wheat germ oils. The obtained results concluded that using pomegranate seeds and wheat germ oils improved the aforementioned biological and biochemical parameters. The best results found by using high doses of pomegranate seeds and wheat germ oils. According to the results, pomegranate seeds and wheat germ oils could be used for improving lipid profile and liver functions in hyperlipidemic rats.
Arabic gum has been used as anti-inflammatory agent and chamomile has anti-inflammatory and antioxidant properties.This study investigated the efficacy of aqueous extracts of chamomile and Arabic gum on the toxic side effects of indomethacin in male albino rats. Thirty male albino rats (185±10 g) were divided into six groups, one of them was kept as a (-ve) control group (5 rats), while the other groups 25 rats were treated orally with indomethacin (25mg / kg b.Wt.) once daily for twentyone (21) days. One group was kept as (+ve) control group, while others were given aqueous extracts of chamomile for 2 groups and Arabic gum for the other 2 groups(500 and 1000 mg/kg) orally daily. Feed intake (FI), body weight gain % (BWG %) and feed efficiency ratio (FER) were carried out. Serum glutamic oxaloacetic transaminase(GOT) and serum glutamic pyruvic transaminase (GPT) were evaluated. Serum creatinine and urea were analyzed. Red blood cell and white blood cells count were measured. Hemoglobin concentration was estimated. Also, histopathological changes for liver were examined.The obtained results concluded that using the tested drinks improved previous mentioned parameters. The best results were obtained on using the high doses of aqueous extracts. According to the results, the author recommended the trial on human beings.
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