In real-time system, the Infrared Focal Plane Array (IRFPA) should be compensated in traditional method of two-point temperature non-uniformity correction (NUC) before system was used every time, which make the system complex. Based on discussion of traditional two-point temperature NUC algorithm, Two-point temperature NUC based on least mean square(LMS)algorithm was proposed in the paper. In the view of the LMS algorithm theory, the correction gain and offset coefficients were iterated one by one during image processing, so that the expected correction result were obtained in little time. At the same time, the correction and coefficients iteration processes were completed in FPGA and DSP respectively, and make the arithmetic structure simple. The simplified structure, low cost and out-door suitable operation-systems are the merits of the system.

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