publicado na web em 25/07/2018The secondary metabolites of the aerial parts of Phyllanthus acuminatus Vahl (Phyllanthaceae) and the biological activity of one of them were characterized in this study. This chemical investigation led to isolation of two lignans, luclaricin (1), a new arylnaphtalenetypelignan, and justicidin B (2). The structures of isolated compounds were determined based on 1D and 2D-NMR, HRESIMS and IR. The cytotoxic activity of justicidin B was assessed against tumor cell lines (MCF-7, U251, NCI-ADR/RES, NCI-H460, OVCAR-3, HT29 and K562) and a non-tumor cell line (HaCat) using sulforhodamine B assay. Justicidin B showed strong cytotoxic activity against the tumor cell lines HT29, K562 and U251 with GI 50 values of 2.28, 3.29 and 5.76 mol L -1 , respectively.

denominado brazoxido A, foi isolado das partes aéreas de Pilocarpus spicatus subsp. Aracatensis Kaastra. Sua estrutura e esteroquímica foi elucidada por métodos espectroscópicos, incluindo as técnicas de ressonância magnética nuclear (RMN) de 1D e 2D, espectrometria de massas de alta resolução com ionização por electrospray (AR-IES-EM), modelagem molecular e comparação com dados da literatura.