The development of a UV Spectrophotometric method for simultaneous estimation of Ranitidine HCl and Naproxen involves absorbance measurement of Ranitidine HCl at 313 nm in pH 7.4 phosphate buffer and 314 nm in both 0.1N HCl and in water and that of Naproxen at 229 nm in pH 7.4 phosphate buffer and 232 nm in both 0.1N HCl and in water corresponding to the respective absorption maxima. Both the drugs obey Beer-Lambert's law in the range of 5-25 µg/ml for Ranitidine HCl and 0.2-1.25 µg/ml for Naproxen. The method developed was validated to determine its linearity, precision, reproducibility and sensitivity. The tablet formulations were evaluated for the percent content of both the drugs at the selected wavelengths and the percent potency were 98.83 and 99.15 for Naproxen and Ranitidine HCl respectively.
Aceclofenac loaded agarose beads were prepared by ionotropic gelation method and drug release profile, swelling index (SI %) and entrapping efficiency (EE %) of aceclofenac were investigated. The drug was dissolved in melted 4 % agar solution in different ratios. Beads were prepared by dropping the hot aqueous solution into a beaker of different percentages of chilled CaCl2 solution followed by filtering the solution and drying at room temperature. The entrapment efficiency was 100±5 %. The swelling index was found to be highest (18.22 % in 4 hours) for beads containing aceclofenac-agar (1:2) in 4 % electrolyte solutions and the swelling property was decreased with increasing electrolyte concentration. In vitro dissolution of beads was carried out in USP apparatus-II (paddle method) at 75 rpm. The drug release was measured by using UVSpectrophotometer at λmax of 268 nm for acid media and 274 nm for buffer media. The dissolution data were treated with zero order, first order and Higuchi model. Half of the formulations were fitted to Higuchi model and rest half to first order model. Finally it can be concluded that with the increasing polymer (agar) concentration, the release rate of aceclofenac was decreased and swelling index was increased and with the increasing electrolyte concentration, the release rate was increased and swelling index was decreased.
ABSTRACT:In this present study an attempt has been made to evaluate glyceryl monostearate (GMS) as a rate retarding material to sustain the release ciprofloxacin hydrochloride from the matrix tablet. The solubility of ciprofloxacin hydrochloride was studied. The physical parameters of the prepared tablets were also evaluated. Release kinetics of ciprofloxacin hydrochloride from this sustained release matrix was studied in 0.1 N HCl using United States Pharmacopoeia type-II dissolution apparatus (paddle method). The effect of polymer load, drug load, hydroxylpropylmethylcellulose to compensate glyceryl monostearate (GMS) and different release modifiers were examined. It was observed that the release rate of drug was retarded with the increasing concentration of GMS. The release data were treated in different fashion to identify the release mechanism and it was revealed with few exception that, when GMS is used as single polymer, release of active drug from the prepared matrix tablet appeared to follow the first order kinetics and showed the tendency to follow Korsmeyer model when HPMC 15 cps was used along with GMS. Using release enhancers the release pattern were fitted to first order kinetics. From the f 2 values it can be concluded that the release pattern of P-2, D-1, H-2 and H-3 are similar to P-1, whereas the formula of P-1, D-2 and H-1 were same. MDT values were found to be increased with the increasing amount of polymer (GMS).
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