Development of Glyceryl Monostearate Based Ciprofloxacin Hydrochloride Sustained Release Matrix Tablet: an <i>In vitro</i> Study

Abstract

ABSTRACT:In this present study an attempt has been made to evaluate glyceryl monostearate (GMS) as a rate retarding material to sustain the release ciprofloxacin hydrochloride from the matrix tablet. The solubility of ciprofloxacin hydrochloride was studied. The physical parameters of the prepared tablets were also evaluated. Release kinetics of ciprofloxacin hydrochloride from this sustained release matrix was studied in 0.1 N HCl using United States Pharmacopoeia type-II dissolution apparatus (paddle method). The effect of polymer load, drug load, hydroxylpropylmethylcellulose to compensate glyceryl monostearate (GMS) and different release modifiers were examined. It was observed that the release rate of drug was retarded with the increasing concentration of GMS. The release data were treated in different fashion to identify the release mechanism and it was revealed with few exception that, when GMS is used as single polymer, release of active drug from the prepared matrix tablet appeared to follow the first order kinetics and showed the tendency to follow Korsmeyer model when HPMC 15 cps was used along with GMS. Using release enhancers the release pattern were fitted to first order kinetics. From the f 2 values it can be concluded that the release pattern of P-2, D-1, H-2 and H-3 are similar to P-1, whereas the formula of P-1, D-2 and H-1 were same. MDT values were found to be increased with the increasing amount of polymer (GMS).

Solvent-free temperature-facilitated direct extrusion 3D printing for pharmaceuticals

“…GMS is a poorly water soluble excipient used in food, cosmetic and pharmaceutical applications for its emollient, emulsifier and plasticiser properties (28). In solid dosage forms, it is usually added as a lubricant (29) or a sustained-release matrix (30)(31)(32). Eudragit ® RL and RS are insoluble poly(meth)acrylates with pHindependent swelling hydration behaviour with high and low water permeability, respectively (24).…”