Background:
Cancer is a common disease caused by the excessive proliferation of cells, and
neurodegenerative diseases are the disorders caused due to the degeneration of neurons. Both can be
considered as diseases caused by the dysregulation of cell cycle events. A recent data suggests that
there is a strong inverse association between cancer and neurodegenerative disorders. There is indirect
evidence to postulate Brain-derived Neurotrophic Factor (BDNF) as a potential molecular link in this
association.
Discussion:
The BDNF levels are found to be downregulated in many neurodegenerative disorders and
are found to be upregulated in various kinds of cancers. The lower level of BDNF in Alzheimer’s and
Parkinson’s disease has been found to be related to cognitive and other neuropsychological impairments,
whereas, its higher levels are associated with the tumour growth and metastasis and poor survival
rate in the cancer patients.
Conclusion:
In this review, we propose that variance in BDNF levels is critical in determining the
course of cellular pathophysiology and the development of cancer or neurodegenerative disorder. We
further propose that an alternative therapeutic strategy that can modulate BDNF expression, can rescue
or prevent above said pathophysiological course. Larger studies that examine this link through animal
studies are imperative to understand the putative biochemical and molecular link to wellness and disease.
Background: The state of disarray from unhygienic conditions and excessive litter throughout urban highways, alleyways, and byways across rural and urban localities of India is abysmal. Such unsanitary conditions impinge upon the future health and welfare of its citizens, tourists and economic development. Purpose: The NRL volunteered PGIMER's campus hygiene initiative" is a pioneering effort spearheaded in compliance with Indian Prime Minister's call that citizens of India work together to establish a cleaner and healthier environment. Methods: A group of 15 highly motivated students in the Neuroscience Division of the PGIMER, worked together vigorously 2 hours a week to affect a cleaner urban environment in the city. Result: The results were national Kayakalp and Skoch award to PGIMER as the cleanest hospital in the country, the vendors or patients no longer litter around the campus, the pot holes have been converted into greener patches, signs board adorn the campus. Conclusion: To inspire citizens through faculty-student led sanitation programs.
Background: Attempts for Guinness world record have continued worldwide but these attempts were rarely aimed to promote public health. Diabetes is one of the rapidly growing lifestyle disorders in India which requires awareness reinforcements among the local population. In recent studies, Yoga has proved to be useful in lifestyle modification and Diabetes management. However, most individuals from rural and urban localities in the country are unaware of this fact. Purpose: The purpose was to organizing a nationwide attempt under the Niyantrit Madhumeh Bharat (NMB) programme to break the world record to be the largest Diabetes lesson, to spread awareness among general population. Methods: Present article represents the perspective of the Chandigarh chapter of NMB programme and its experience in Guinness world record attempt. Diabetes awareness lesson was organized in the city as per the standards defined by the Guinness Book and outcomes of the entire campaign were assessed at the end of the campaign. Result: Total 498 individuals participated in the campaign. Among them, 268 participants were questioned at the end of the campaign about the role of Yoga in Diabetes. 247 participants (92%) were agreed that Diabetes can be modified by Yoga and 9 participants (3%) disagreed. The remaining 12 participants (5%) did not give any response. Conclusion: We noticed that most of the participants became aware of the role of Yoga in Diabetes.
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