No abstract

The ovaries are a critical source not only of estrogen but also of testosterone. On removal of the uterus, even in instances where ovaries have been spared, their function can be compromised. Women who have had a simple hysterectomy (ovaries remaining intact), even if treated postsurgically with supplementary estrogen, have three times the risk of cardiovascular disease compared with women who have not had a hysterectomy. In men, testosterone has been demonstrated to have beneficial fibrinolytic effects and beneficial effects on blood vessel endothelium, in blood sugar and insulin metabolism, and in maintaining coronary artery circulation. Studies on the potential cardiovascular protective effects of physiologic levels of testosterone in women are critically needed. Restoring a physiologic level of testosterone to women after hysterectomy not only can improve quality of life in terms of sexual libido, sexual pleasure, and sense of well-being but also can build bones--and may be a key to protecting cardiovascular health. Women developing testosterone deficiency as a consequence of natural aging/menopause may similarly benefit from physiologic testosterone supplementation.

Hysterectomy has the potential for generating serious consequences in terms of health, including two to seven times greater incidence and prevalence of cardiovascular disease, and quality of life, including loss of sexual libido and pleasure. More than a half-million American women undergo hysterectomy every year. Both in premenopausal women and in postmenopausal women, the ovaries are a critical source not only of estrogen but also of testosterone. Even in instances where ovaries have been spared on removal of the uterus, their function may be compromised. Today, women for whom estrogen replacement therapy is not contraindicated are routinely given supplemental estrogen following hysterectomy/oophorectomy. Many women develop and suffer symptoms of testosterone deficiency that go unrecognized and untreated. Testosterone supplemental therapy for women following hysterectomy not only can improve the quality of their lives in terms of sexual libido, sexual pleasure, and sense of well-being but also can--as does supplementary estrogen--contribute to the prevention of osteoporosis. Most importantly, an increasing body of evidence suggests that testosterone may be cardiovascular protective. As testosterone, the most potent anabolic steroid, has some anabolic effect on virtually every tissue in the body, it is likely that supplementing testosterone to physiological levels contributes to health maintenance in as yet undefined ways and that testosterone deficiency in women may be costing more in morbidity and mortality than we know at present.

No abstract

To determine whether a putative human sex-attractant pheromone increases specific sociosexual behaviors of postmenopausal women, we tested a chemically synthesized formula derived from research with underarm secretions from heterosexually active, fertile women that was recently tested on young women. Participants (n = 44, mean age = 57 years) were postmenopausal women who volunteered for a double-blind placebo-controlled study designed, to test an odorless pheromone, added to your preferred fragrance, to learn if it might increase the romance in your life. During the experimental 6-week period, a significantly greater proportion of participants using the pheromone formula (40.9%) than placebo (13.6%) recorded an increase over their own weekly average baseline frequency of petting, kissing, and affection (p = .02). More pheromone (68.2%) than placebo (40.9%) users experienced an increase in at least one of the four intimate sociosexual behaviors (p = .04). Sexual motivation frequency, as expressed in masturbation, was not increased in pheromone users. These results suggest that the pheromone formulation worn with perfume for a period of 6 weeks has sex-attractant effects for postmenopausal women.