Objective: In this study, it was aimed to investigate in vitro activity of moxifl oxacin and rifampicin on biofi lm formation by clinical MRSA isolates. Background: Methicillin resistant Staphylococcus aureus (MRSA) strains could be the causative agent in chronical and medical device associated infections by biofi lm formation. Methods: Moxifl oxacin and rifampicin MIC values of 98 MRSA clinical isolates were determined by microdilution method. Biofi lm formation of all isolates was determined in 96-well microplates by using spectrophotometric method. Effects of MIC and sub-inhibitory concentrations (1/2 and 1/4 MIC) of antibiotics on biofi lm formation were examined in 46 strong biofi lm producer strains. Results: Biofi lm production decreased in 37 and 44 isolates at all studied concentrations of moxifl oxacin and rifampicin, respectively. Biofi lm production increased in six isolates with moxifl oxacin and in two isolates with rifampicin. Coclusion: Biofi lm inhibitory effect of rifampicin was found to be stronger than moxifl oxacin in the examined strains. The studied antimicrobials also induced biofi lm formation in some strains. Results of this study may help to evaluate the effects of these antibiotics on biofi lm formation of clinical MRSA strains and to control the antibiotic resistance in clinical settings (Tab. 2, Ref. 25).
The present study aimed to evaluate antimicrobial activity of tigecydcline against 84 multidrug resistant (MDR) Acinetobacter spp. strains by disc diffusion and E-test methods. The results of disc diffusion test were compared according to two different interpretation ways. In addition, E-test results and the disc diffusion results that interpreted by both the methods were checked for compatibility. According to the disc diffusion test, 3 strains (3.57%) were found resistant to tigecycline when considering breakpoints suggested by Food and Drug Administration (FDA). On the other hand, none of the strains was found resistant to the evaluation criteria recommended by Jones etal. (2007). Considering E-test results of tigecycline, MIC, and MICG, values of tigecycline for Acinetobacter spp. were 0.75 and 1 mg/l, respectively. Based on FDA defined breakpoints for Enterobacteriaceae, any resistant isolate was detected. In conclusion, although there are some differences in the results, tigecycline was found quite effective on Acinetobacter spp. isolates with reference to the both disc diffusion and the E-test methods.
Introduction:Alternaria is a common saprophyte, which is usually not pathogenic in humans. Generally, local wounds infections of Alternaria occur with presence of immunosuppression factors such as HIV infection and renal transplant patients.Case Presentation:We reported a case of wound infection induced by Alternaria spp. in a renal transplant patients. The main interest in this case was the rareness of the cutaneous alternariasis, its clinical aspects and good response to therapy. Recognition of Alternaria spp. as potential opportunistic pathogens is important for differential diagnosis of dermatological lesions, such as granulomatous or ulcerative lesions in immunocompromised patients.Conclusions:Alternariasis or similar cases may be increased due to the increased number of immunosuppressed patients. From this point of view, skin lesions in these patients must be planned and microbiologically evaluated considering the molds.
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