Corona viruses enveloped positive-sense RNA viruses causes various diseases in mammals as well as birds which range from upper respiratory tract infection to potentially lethal human respiratory syndrome. In humans, Severe Acute Respiratory Syndrome corona virus 2 (SARS-CoV-2) causing corona virus disease 2019 (COVID-19) which shows symptoms like fever, sore throat, gasping and ultimately pneumonia, lung injury and leading to death. The virus acts on various systems of our body, and one of them is the Renin-Angiotensin system. It is supposed that the virus causes cell injury by acting on Angiotensin-Converting Enzyme 2 (ACE2) receptors which causes an increase in the level of Angiotensin II, leading to inflammation and lung injury. An essential vitamin can prevent this in our body that is vitamin D. It acts on Renin-Angiotensin system (RAS) by inhibiting the action of renin and also by increasing production of ACE2 and hence Angiotensin II level decreases which prevent inflammation and lung injury. So vitamin D has a remarkable and pivotal role in modulation of the immune system of our body and hence protects human from this fatal disease.
Introduction:
Areca nut (AN) affects oral cavity as well as various body systems. Its adverse effects on oral cavity are widely reported in the literature. However, limited studies described its systemic effect. Thus, the present study was undertaken to evaluate the association of AN habit with diabetes mellitus (DM) and its correlation with liver toxicity.
Aim:
The aim of the present prospective study was conducted in the Department of Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital and the Department of General Medicine, AVBRH Sawangi (Meghe), Wardha, to determine the correlation between AN, DM, and liver toxicity.
Methods:
The present study included 280 patients suffering from DM. They were assessed for medical history which included age at the onset and duration of DM. Detailed AN habit history was recorded that included the type of the habit, age at which the habit was started, and duration of habit. To evaluate the correlation of DM with liver damage, liver enzymes were estimated.
Results:
The positive correlation was observed between duration of DM and duration of AN chewing habit. The habitual patients suffered from disease at an early age (36.25 ± 7.62 years) as compared to nonhabitual (47.56 ± 4.89 years). Furthermore, there was a positive correlation between duration of disease and duration of habit with increased liver enzymes which is an important factor determining liver toxicity.
Conclusion:
A positive association was noted between AN habit and DM and also with liver toxicity.
Aim: To determine the efficacy of J grandiflorum in the treatment of aphthous ulcer on the basis of reduction in size of the ulcer, erythema and pain.
Study Design: Prospective, Observational.
Place and Duration: Department of Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Deemed to be University, Sawangi (Meghe), Wardha.
Duration: One year.
Methodology: One Hundred and Twenty patients visiting to the dental OPD and diagnosed to have aphthous ulcer will be selected. The patients will be divided in three groups and the formulated gel will be prescribed to one group of patient and other will be given corticosteroid and monitoring will be done.
Expected Results: With all the studies performed till now it is expected that the j. grandiflorum and honey together will have good synergistic effect over aphthous ulcer and will help in reduction of size, pain and erythema level of aphthous ulcer.
Conclusion: J grandiflorum and honey may be effective in management of recurrent aphthous stomatitis.
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