In L-arginine metabolizing pathways, arginase and nitric oxide synthase are regulated in a reciprocal manner. In recent years, nitric oxide has been proposed as a key player in hyperthyroidism. The importance of arginase in arginine control has not yet been studied in hypothyroidism. The goal of this study was to examine the activity of arginase in in type 2 diabetic patients with and without hypothyroidism. The two most popular endocrinopathies that exist in clinical practice are thyroid disease and diabetes mellitus DM. The thyroid hormones, on the other hand, control the metabolism of carbohydrates and the pancreas activity. The study group consisted of 120 subjects divided into four groups; the first group included 30 healthy control subjects, the second group included 30 patients with both hypothyroidism and type 2 DM, the third group included 30 patients with hypothyroidism without type 2 diabetes (T2DM) and the fourth group included 30 patients with T2DM without hypothyroidism. The concentration of fasting serum glucose (FSG), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low-density lipoprotein (VLDL), triiodothyronine (T3), thyroxin (T4), thyroid-stimulating hormone (TSH) were determined.
The production of free radicals is a major component of the oxidative stress that occurs in biological systems. This is linked to the development of various diseases, including diabetes and hypothyroidism. The presence of these free radicals can also affect the functioning of the antioxidant enzymes. Catalase is an important component of the antioxidant enzymes that protect cellular structures from the damage caused by free radicals. It also neutralizes the reactive oxygen species by preventing them from reacting with metal catalysts. The study was conducted to investigate the effects of Catalase on the activities of various antioxidants in people with diabetes and hypothyroidism. Depression of metabolism by hypothyroidism has been reported to decrease oxidant production and thus protect tissues against oxidant damage. The study included 120 subjects divided into four groups; the first group included 30 healthy control subjects, the second group includes 30 patient’s hypothyroidisms with type 2 DM, the third group included 30 patient’s hypothyroidisms only and the fourth group included 30 patients with type 2 DM only.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.