There are many questions still remain concerning the relationship between the trace elements and thyroid hormones. Therefore, this study was undertakento evaluate the concentration levels of some trace elements (zinc, copper, selenium, manganese, magnesium), and to reach the possible correlation between these trace elements and thyroid hormones in hypothyroidism.The study was included 50 patients with hypothyroidism and 28 healthy volunteers' serves as control group matched with age, sex, and body mass index (BMI). All participant had not taken vitamin or mineral supplements for at least 2 weeks before sampling, blood sampling were drawn to determine the serumtrace elements levels (Zn, Cu, Se, Mn, and Mg), thyroid hormone (T3, T4, and TSH), and lipid profile (TC, TG, LDL, HDL, and VLDL). The results indicate that the hypothyroidism patients have significant increase in TSH levels (P< 0.01), and significant decrease in T3, T3/T4 levels (P<0.001), although, there were decrease in serum trace elements (Se, Zn, Cu, Mn, and Mg) in hypothyroidism patients compared with controls group, (P< 0.001 for all serum Se, Zn, Cu, Mn, and P< 0.01 for Mg). The results indicate that there was no significant correlation between serum Cu, Mn, Mg and T3, T4, and TSH level; but, there was a significant positive correlation between Se-T3 (r=0.286, P<0.04), and Zn-T3 (r=0.3, P<0.01), also there was only a significant negative correlation between serum Se-TSH levels (r=-0.315, P< 0.02) in hypothyroidism patients. There is significant increase in the mean serum cholesterol (TC), triglycerides (TG), and low density lipoprotein (LDL) in patients compared with normal controls (P 0.01, P<0.001, <0.05) respectively. Also, there is significant decrease in the mean serum concentration of high density lipoprotein (HDL) in the patients with hypothyroidism than control, and our results showed that there is positive correlation between TSH levels and lipid (cholesterol, triglyceride, and very low density lipoproteins), although, there is negative correlation between Mg concentration and lipid (TC, TG, LDL) levels. We conclude that the trace elements Se, Zn, Cu, Mn, and Mg have altered in hypothyroidism patients; there are correlations between some trace elements (Se, and Zn) and thyroid hormones, but there are no obvious correlations between the other trace elements (Cu, Mn, and Mg) status and thyroid hormones. That is means there is an interactions between some trace elements and thyroid hormones levels.
Background: thalassemia is one of most dangerous disease; it is an inherited impairment of hemoglobin production, in which there is partial or complete failure of the synthesis of globin chain.Objective: the aim of this study is to determine the prevalence of Hepatitis C Virus (HCV) infection among thalassemic patients in Ibn-albalady hospital in Baghdad. Patients and methods:The study was carried out on 111 transfusion dependent beta-thalassemia (74 males and 37 females) with a mean age 12.51 yrs attending to the Ibn Alba lady Hospital, in Baghdad during the period March 2008 to September 2008. The control group was thirty one (12 males and 19 females) with mean age of 11.5 yrs and investigated to serve as a control group; they were randomly selected from community. Blood sample was collected in morning for biochemical assays (hepatitis C virus (HCV), Glutamic Oxaloacetic (GOT),Glutamic Pyruvic Transaminase (GPT), Alkaline phosphates (ALP), Total serum bilirubin (TSB), Direct serum bilirubin( Dir.SB), Indirect serum bilirubin (Indir.SB). Results: Out of 111 thalassemic patients there was 51 (46 %) sera was confirmed positive for anti-HCV-antibodies. The remaining 60 (54 %) were seronegative, while among 31 healthy controls only one (3.22%) was seropositive the result was statistically of a high significant difference (P=0.0001).Out of 51 seropositive, 13 (72.3%) patients were positive among those above 20 years, while only one (16.7) was positive among those from (0 4) years. It was found no significant correlation in (sex, TSB, Indir.SB, ALP) between patients with HCV+ve compared with HCV −ve. The current study demonstrated that there was a highly significant difference in (GPT, GOT, and Dir.SB) levels between patients with seropositive HCV and patients with seropositive HCV. Conclusions:The main causes of liver injury in thalassemia are hepatitis C virus and the finding suggests that HCV is the main cause of abnormal liver function in patients with thalassemia.
In L-arginine metabolizing pathways, arginase and nitric oxide synthase are regulated in a reciprocal manner. In recent years, nitric oxide has been proposed as a key player in hyperthyroidism. The importance of arginase in arginine control has not yet been studied in hypothyroidism. The goal of this study was to examine the activity of arginase in in type 2 diabetic patients with and without hypothyroidism. The two most popular endocrinopathies that exist in clinical practice are thyroid disease and diabetes mellitus DM. The thyroid hormones, on the other hand, control the metabolism of carbohydrates and the pancreas activity. The study group consisted of 120 subjects divided into four groups; the first group included 30 healthy control subjects, the second group included 30 patients with both hypothyroidism and type 2 DM, the third group included 30 patients with hypothyroidism without type 2 diabetes (T2DM) and the fourth group included 30 patients with T2DM without hypothyroidism. The concentration of fasting serum glucose (FSG), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low-density lipoprotein (VLDL), triiodothyronine (T3), thyroxin (T4), thyroid-stimulating hormone (TSH) were determined.
The main objective of this study would be that if serum lipocalin-2 and Vaspin levels may be utilized as indicators for chronic in Type 2 diabetes mellitus (T2DM) patients. T2DM treatment is to maintain a healthy glycemic level. If this goal is not met, diabetes consequences, both acute and chronic, may emerge, one of which is obesity. As a result, researchers have investigated the levels of Lipocalin-2 and Vaspin, as well as their connection to obesity and insulin resistance. In this study, we included 60 T2DM (ages 35 to 65 years) and 30 healthy controls. After an overnight fast, blood serum samples were collected, and routine biochemical parameters such as lipocalin-2, Vaspin, and glucose were measured in all samples. At a P <0.05 level, the data were declared significant. Using an ELISA kit, the levels of serum Lipocalin-2 and Vaspin were measured. The results have shown that patients with T2DM had substantially greater blood serum levels of Lipocalin-2 and Vaspin than normal controls (P <0.001 for all comparisons). Also, results revealed Lipocalin-2 and Vaspin have a high positive correlation with each of BMI and Homeostasis Model Assessment for insulin resistance HOMA-IR and moderate positive correlation between Vaspin and Fasting blood glucose.
This study was aimed to determine bone formation markers (OST and BALP) and lysyl oxidase in diabetes and non-diabetes Iraqi acromegaly patients in addition to find the relationship among these parameters. The present study conducted 60 acromegalic patients (30 diabetes & 30 non diabetes) attending National Diabetes Center / AL-Mustansiriya University/Baghdad, and 30 healthy individuals as a control group aged (35-60) years. All patients were administrated Sandostatin drug, and they were diagnosed by physician in the hospital.FBG, GH, IGF-1, OST, BALP, and LOX were determined in all groups. The results showed a highly significant rise in all parameters (GH, IGF-1, FBG, OST, BALP, and LOX values in serum of all patients when compared with normal individuals. There were a positive highly significant correlations for lysyl oxidase with osteocalcin and a positive significant with BALP in acromegalic patients. We concluded that lysyl oxidase may be a novel biomarkers in endocrine diseases like acromegaly.
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