Zeolite has been used as an efficient and a novel heterogeneous catalyst for one-pot synthesis of biologically active drug-like molecules, amidoalkyl naphthols. This green route involves multicomponent reaction of 2-naphthol, aromatic aldehydes and amide in the presence of a catalytic amount of zeolite H-Beta (H-BEA) under solvent reflux as well as solvent-free conditions.
A series of dihydropyrimidin-2(1H)-one (DHPM) belongs to one of the important class of therapeutic and pharmacological active compound, were synthesized through the multicomponent reactions (MCRs) of aldehydes, ethyl acetoacetate and urea, followed by the heterogeneous catalyzed Biginelli reaction. In the present endeavour, medium (ZSM-5) and large pore zeolites (Y, BEA and MOR) as well as dealuminated zeolites BEA, were studied as catalysts. An excellent activity for DHPMs synthesis is achieved by optimizing accessibility of the reactants to the active sites and the surface polarity of zeolite catalysts. Moreover, the mechanism of Biginelli reaction was studied by means of GAUSSVIEW energy calculations of adsorbed acylimine intermediate on zeolite by using the density functional method (DFT).
Graphite supported bismuth trichloride based green, heterogeneous and recyclable catalyst was developed and utilized for the preparation of β-enaminones from amines using tetrahydrofuran (THF) as a solvent system at 66 °C temperature. Catalyst was found to produce high to excellent yields and was exhibited as a potent catalyst to produce the titled compounds. Further, the catalyst could also be recovered easily from reaction system and readily reused with minimal loss of activity.
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