Zeolite H-BEA catalysed multicomponent reaction: One-pot synthesis of amidoalkyl naphthols – Biologically active drug-like molecules

Abstract

Zeolite has been used as an efficient and a novel heterogeneous catalyst for one-pot synthesis of biologically active drug-like molecules, amidoalkyl naphthols. This green route involves multicomponent reaction of 2-naphthol, aromatic aldehydes and amide in the presence of a catalytic amount of zeolite H-Beta (H-BEA) under solvent reflux as well as solvent-free conditions.

Sustainable Synthesis of Dibutyl Itaconate from Biomass Derived Acid via Esterification Reaction over Hierarchical Zeolite H-BEA Catalysts

“…In terms of application, BEA zeolite is known to be the best and most widely used zeolites. High acid site accessibility, high thermal stability, and suitable acidity are all ensured by its three-dimensional pore structure, which is composed of channels having 12-membered ring and diameters of 0.55 × 0.55 nm and 0.76 × 0.64 nm [23]. Owing to peculiar pore structure and local defects of zeolite H-BEA, it is widely used as heterogeneous solid acid catalyst in wide spectrum of industrial unit operations established to carry out key organic transformations.…”

One-pot synthesis of 1-amidoalkyl-2-naphthols catalyzed by melamine-Br3 under solvent-free conditions

“…1-Amidoalkyl-2-naphthols can be prepared by the multicomponent condensation of aryl aldehydes with 2-naphthol and acetamide or thioacetamide in the presence of an appropriate catalyst such as RuCl2(PPh3)3 [6], sulfamic acid [7,8], Ce(SO4)2 [9], [FemSILP]-L-prolinate [10], Bi(NO3)3•5H2O [11], K5CoW12O40•3H2O [12], Hf(NPf2)4 [13], H3PW12O40 [14], Yb(OTf)3 [15], Fe(HSO4)3 [16], montmorillonite K10 clay [17], p-TSA [18], H4SiW12O40 [19], zeolite [20], 2,4,6-trichloro-1,3,5trizine [21], iodine [22], PFPAT [23], and poly(4-vinylpyridinium butane sulfonic acid) hydrogen sulfate [24].…”

Magnesium Sulfate Promoted Efficient and Green Synthesis of Aminoalkyl, Amidoalkyl and Diarylmethane Derivatives

“…1). Assorted varieties of catalysts/reagents are reported in literature for substituted amidoalkyl and aminoalkyl naphthol synthesis [6][7][8][9] . However, several methods have limitations such as tedious preparation procedure of catalysts, corrosive and/or toxic nature of reagents, use of organic solvents, difficult product isolation processes, etc.…”