Fine needle aspiration cytology (FNAC) is an important diagnostic tool for swellings in the thyroid, salivary gland, breast lump and enlarged lymph nodes. Very few studies have been done to explore the potential of FNAC in the diagnoses of intraoral lesions. Hence the present study was done to find out the efficacy of FNAC in the diagnosis of intraoral lesions. AIMS/OBJECTIVES: To determine the efficacy of Fine Needle Aspiration Cytology in the diagnosis of intraoral lesions. MATERIALS & METHODS:A prospective study on 88 cases presented with intraoral lesions was done from August 2010 to July 2012. Cases of intraoral Cases having both FNACs along with biopsy correlation were included. OBSERVATIONS/RESULTS: The age group ranged from 12-83 years with male: female ratio of 1.6:1. The most common sites of aspiration were tongue in 28 cases, followed by buccal mucosa in 24 and other sites 42 cases. The lesions reported on FNAC were malignant tumors in 44(50%), benign lesions 39 (44.31%) and suspicious for malignancy 5(5.69%) cases. False negative and false positive were 6 and 2 cases respectively. Squamous cell carcinoma was the common malignant tumor. Overall sensitivity of 88%, specificity 95.6% and diagnostic accuracy of 91.6% was obtained in our study. CONCLUSION: We conclude that FNAC is one of the important diagnostic tool in the diagnosis of intraoral lesions. The results of our study suggest, it should be considered as first line of investigation, especially in clinically suspected malignant tumors.
Breast tissue reacts to estrogen and progesterone stimulation, not only during puberty, pregnancy and lactation, but during each menstrual cycle. As the menopausal period is approached and postmenopausal period evolves, progressive atrophy of the epithelial and connective tissue components of the breast occurs. The loose connective tissue becomes dense and hyalinized and finally, the lobule is converted into ordinary stroma which in the process of involution is replaced by fat. All patients undergoing core needle biopsy of breast were selected for the study. An informed consent will be taken for the procedure. Under local anesthesia using 14 G needle, ultrasound guided core needle biopsy will be performed by radiologist. The biopsy specimen will be sent to histopathology department in 10% formalin. The tissue will be processed, stained with haematoxylin and eosin and examined microscopically. In present study, the most common presenting complaint is breast lump comprising of 59 cases (98.3%). Out of 59 cases 31 cases (51.7%) had lump on left side, 28 cases (46.7%) had lump on right side.1 case had no lump (1%). In the present study 41 cases underwent mammogram, 24 cases (58.5%) showed BIRADS 5 scoring followed by BIRADS 4 in 12 cases (29.3%) and BIRADS 2 in 5 cases (12.2%).
Breast cancer is the most common cancer in women both in the developed and developing world. In India, the age adjusted incidence of breast cancer in urban areas ranges between 20-30 per 1,00,000 population. Core needle biopsy (CNB) has been the first approach in cases of large lesions clearly malignant at mammogram. Therefore, CNB enables more definitive diagnosis than FNAC to differentiate benign and malignant tumors. A sample size of 60 cases are included in this study. The specimens sent to the department of pathology will be processed by routine histopathological techniques. Data is entered in SPSS and analyzed. Chi-square test is used to find sensitivity, specificity, NPV and PPV of core needle biopsy. Among benign lesions, mastitis comprising of 5 cases (11.5%). Among malignant cases IDC -NST was most common type comprising of 27 cases, 8 cases were inconclusive. Out of 60 cases 50 cases underwent mastectomy/lumpectomy, 7 were benign and 43 were malignant. All 50 cases were correlating with core needle biopsy diagnosis. 8 cases which were inconclusive in CNB underwent mastectomy/lumpectomy as BIRADS/FNAC were showing carcinoma features. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) are 86.6%, 100%, 86.6% and 100% respectively.
Introduction: Bronchoalveolar lavage (BAL) fluid analysis helps in early detection, rapid diagnosis and treatment of lung cancer as the therapy is based on subtyping. BAL has an important role in diagnosis of peripherally situated bronchoscopically invisible primary lung cancers, most of which are adenocarcinomas. Purpose: This study aims to detect diagnostic accuracy of BAL fluid analysis in detection of lung cancers. Materials and Methods: This retrospective cum prospective study in a tertiary care hospital involved analysis of BAL fluid obtained by lavage of respiratory tract in clinically and radiologically suspected lung lesions for 4 years from January 2012 to December 2016. Results: Out of 169 BAL fluids received, 38 (22.4%) were positive for malignancy. Squamous cell carcinoma is the most common cancer noted in our study. BAL was reported falsely negative for malignancy in 49 cases (56.7%) proved by lung biopsy. BAL was reported falsely negative for malignancy in 49 cases (56.7%) proved by lung biopsy. One false positive case was noted in our study. The sensitivity of BAL was 43% and specificity of BAL was 98.8% in our study. The positive predictive value of BAL in the diagnosis of lung cancers is 97.36%. The negative predictive value of BAL in the diagnosis of lung cancers is 62.59%.The diagnostic accuracy of BAL is 70.4%. Conclusion: BAL fluid analysis provides a rapid, reliable process to detect, subtype malignancies of the lower respiratory tract both in bronchoscopically visible and invisible tumours.
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