Breast tissue reacts to estrogen and progesterone stimulation, not only during puberty, pregnancy and lactation, but during each menstrual cycle. As the menopausal period is approached and postmenopausal period evolves, progressive atrophy of the epithelial and connective tissue components of the breast occurs. The loose connective tissue becomes dense and hyalinized and finally, the lobule is converted into ordinary stroma which in the process of involution is replaced by fat. All patients undergoing core needle biopsy of breast were selected for the study. An informed consent will be taken for the procedure. Under local anesthesia using 14 G needle, ultrasound guided core needle biopsy will be performed by radiologist. The biopsy specimen will be sent to histopathology department in 10% formalin. The tissue will be processed, stained with haematoxylin and eosin and examined microscopically. In present study, the most common presenting complaint is breast lump comprising of 59 cases (98.3%). Out of 59 cases 31 cases (51.7%) had lump on left side, 28 cases (46.7%) had lump on right side.1 case had no lump (1%). In the present study 41 cases underwent mammogram, 24 cases (58.5%) showed BIRADS 5 scoring followed by BIRADS 4 in 12 cases (29.3%) and BIRADS 2 in 5 cases (12.2%).
Breast cancer is the most common cancer in women both in the developed and developing world. In India, the age adjusted incidence of breast cancer in urban areas ranges between 20-30 per 1,00,000 population. Core needle biopsy (CNB) has been the first approach in cases of large lesions clearly malignant at mammogram. Therefore, CNB enables more definitive diagnosis than FNAC to differentiate benign and malignant tumors. A sample size of 60 cases are included in this study. The specimens sent to the department of pathology will be processed by routine histopathological techniques. Data is entered in SPSS and analyzed. Chi-square test is used to find sensitivity, specificity, NPV and PPV of core needle biopsy. Among benign lesions, mastitis comprising of 5 cases (11.5%). Among malignant cases IDC -NST was most common type comprising of 27 cases, 8 cases were inconclusive. Out of 60 cases 50 cases underwent mastectomy/lumpectomy, 7 were benign and 43 were malignant. All 50 cases were correlating with core needle biopsy diagnosis. 8 cases which were inconclusive in CNB underwent mastectomy/lumpectomy as BIRADS/FNAC were showing carcinoma features. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) are 86.6%, 100%, 86.6% and 100% respectively.
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