No abstract

Two vaccines together are better than one alone Polio is proving difficult to eradicate. Making the choice between administering a live attenuated vaccine orally (Sabin) or an inactivated vaccine (Salk) by injection has been highly controversial. Patients prefer the Sabin vaccine, but it requires many doses to offer immunity. Jafari et al. tested the two vaccines together in northern India. The injected vaccine significantly reduced virus shedding and boosted intestinal mucosal immunity in children already given the oral vaccine. Thus, using both vaccines could help speed the eventual global demise of polio. Science , this issue p. 922

No abstract

No abstract

No abstract

No abstract

The mucosal immunity induced by OPV in India varies by location, serotype, and vaccine formulation. These findings have implications for global eradication and the potential role played by inactivated vaccine in this setting.

No abstract