Diffuse optical tomography (DOT) non-invasively measures the functional characteristics of breast lesions using near infrared light to probe tissue optical properties. This study aimed to evaluate a new digital breast tomosynthesis (DBT)/DOT fusion imaging technique and obtain preliminary data for breast cancer detection. Twenty-eight women were prospectively enrolled and underwent both DBT and DOT examinations. DBT/DOT fusion imaging was created after acquisition of both examinations. Two breast radiologists analyzed DBT and DOT images independently, and then finally evaluated the fusion images. The diagnostic performance of each reading session was compared and interobserver agreement was assessed. The technical success rate was 96.4%, with one failure due to an error during DOT data storage. Among the 27 women finally included in the analysis, 13 had breast cancer. The areas under the receiver operating characteristic curve (AUCs) for DBT were 0.783 and 0.854 for readers 1 and 2, respectively. DOT showed comparable diagnostic performance to DBT for both readers. The AUCs were significantly improved (P = 0.004) when the DBT/DOT fusion images were used. Interobserver agreements were highest for the DBT/DOT fusion images. In conclusion, this study suggests that DBT/DOT fusion imaging technique appears to be a promising tool for breast cancer diagnosis.
Estimating a dense and accurate depth map is the key requirement for autonomous driving and robotics. Recent advances in deep learning have allowed depth estimation in full resolution from a single image. Despite this impressive result, many deep-learning-based monocular depth estimation (MDE) algorithms have failed to keep their accuracy yielding a meter-level estimation error. In many robotics applications, accurate but sparse measurements are readily available from Light Detection and Ranging (LiDAR). Although they are highly accurate, the sparsity limits full resolution depth map reconstruction. Targeting the problem of dense and accurate depth map recovery, this paper introduces the fusion of these two modalities as a depth completion (DC) problem by dividing the role of depth inference and depth regression. Utilizing the state-of-the-art MDE and our Gaussian process (GP) based depth-regression method, we propose a general solution that can flexibly work with various MDE modules by enhancing its depth with sparse range measurements. To overcome the major limitation of GP, we adopt Kernel Interpolation for Scalable Structured (KISS)-GP and mitigate the computational complexity from O(N 3 ) to O(N ). Our experiments demonstrate that the accuracy and robustness of our method outperform state-of-the-art unsupervised methods for sparse and biased measurements.
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