Diets high in calories and sweetened foods with disaccharides frequently lead to exaggerated postprandial spikes in blood glucose. This state induces immediate oxidant stress and free radicals which trigger oxidative stress-linked diabetic complications. One of the therapeutic approaches for decreasing postprandial hyperglycemia is to retard absorption of glucose by the inhibition of carbohydrate hydrolyzing enzymes, α-amylase and α-glucosidases, in the digestive organs. Therefore, the inhibitory activity of Korean onion (Allium cepa L.) extract against rat intestinal α-glucosidases, such as sucrase, maltase, and porcine pancreatic α-amylase were investigated in vitro and in vivo. The content of quercetin in ethyl alcohol extract of onion skin (EOS) was 6.04 g/100 g dried weight of onion skin. The in vitro half-maximal inhibitory concentrations (IC50) of EOS and quercetin, a major phenolic in onion, on rat intestinal sucrase were 0.40 and 0.11 mg/mL, respectively. The postprandial blood glucose lowering effects of EOS and quercetin were compared to a known type 2 diabetes drug (Acarbose), a strong α-glucosidase inhibitor in the Sprague-Dawley (SD) rat model. In rats fed on sucrose, EOS significantly reduced the blood glucose spike after sucrose loading. The area under the blood glucose-time curve (AUClast) in EOS-treated SD rats (0.5 g-EOS/kg) was significantly lower than in untreated SD rats (259.6 ± 5.1 vs. 283.1 ± 19.2 h·mg/dL). The AUClast in quercetin-treated SD rats (0.5 g-quercetin/kg) was similar to in EOS-treated group (256.1 ± 3.2 vs. 259.6 ± 5.1 h·mg/dL). Results from this study indicates that although quercetin does have blood glucose lowering potential via α-glucosidase inhibition, there are other bioactive compounds present in onion skin. Furthermore, the effects of two weeks administration of EOS in a high carbohydrate-dietary mixture (Pico 5053) on sucrase and maltase activities in intestine were evaluated in SD rat model. Compared to the upper and middle parts of intestine, the activities of sucrase in the lower parts of intestine remained significantly higher after two weeks of EOS treatment. These results indicate that EOS may improve exaggerated postprandial spikes in blood glucose and glucose homeostasis since it inhibits intestinal sucrase and thus delays carbohydrate absorption, although clinical trials are needed.
-An experimental study was conducted to evaluate the static shear strength of stirrup-reinforced cast-in anchors. The test parameters considered herein are an existence of front bearing bar and concrete crack. M36 anchor was used with an edge distance of 180mm. HD-10 bars were used for all reinforcing bars and the stirrups were placed with 100mm spacing. The shear resistance increased by 16% when the front bearing bar was installed. Meanwhile, the resistance reduced only 5% in the cracked concrete compared with the uncracked concrete. The test results showed that ACI 318 and ETAG 001 specifications could estimate the shear strength of stirrup-reinforced anchors conservatively and a rational method was proposed. A consideration on the fracture strength of stirrup-reinforced anchor is also given.
-In this study, an experimental study was performed to evaluate the concrete breakout strength of unreinforced cast-in-place anchors by seismic qualification test under shear loading. The CIP anchors tested herein were 30mm in diameter with an edge distance of 150mm and an embedment depth of 240mm in uncracked and cracked concrete. The cracked specimen consisted of orthogonal and parallel crack to the loading direction, respectively. The dynamic loading sequence during the seismic qualification test was determined based on CSA N287.2, ACI 355.2 and ETAG 001 codes. After the dynamic loading, the static loading was applied until failure occurs. The shear resistance by seismic qualification tests showed almost the same strength as that obtained from the static tests in uncrcaked and cracked concrete, respectively. Meanwhile, the breakout depth did not reach , therefore the modified strength equation of ACI 318-11 could estimate properly the concrete breakout strength, which does not consider effective bearing length. Keywords -Cast-in-place anchor, Seismic qualification test, Uncracked concrete, Cracked concrete, Shear resistance, Effective bearing length
-In this paper, a series of experiments for the evaluation of flexural resistance of longitudinally stiffened plate girder with slender web were conducted. For the purpose, four plate girder specimens with and without longitudinal stiffener were fabricated for the web slenderness of 219 and 156. The test results were compared with the current AASHTO LRFD and Eurocode 3 codes, respectively. As presented in the previous paper by the authors, it was acknowledged that the AASHTO LRFD code could considerably underestimate the flexural resistance of longitudinally stiffened girder with slender web and the proposed method in the previous paper could estimate the flexural resistance reasonably.
-This study evaluated the static and dynamic shear strength of cast-in-place anchors reinforced with hairpin bars in uncracked and cracked concrete. The anchors 30mm in diameter reinforced with D10 hairpin bar were designed with an edge distance of 150mm and an embedment depth of 240mm. The cracked specimens consisted of the orthogonal and parallel cracks to the direction of shear loads, respectively. The dynamic strength was evaluated using seismic qualification tests based on the ACI 355.2 standard. The shear strength of the hairpin reinforced anchor was hardly correlated to the concrete cracks and the dynamic strength was similar to its static shear strength. Finally, a consideration on the design strength of hairpin reinforced anchors was presented. Keywords -Hairpin-reinforced, Cast-in-place anchor, Shear strength, Seismic qualification test, Uncracked and cracked concrete 에서 인장
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