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One of the most severe health diseases affect the mankind is cancer. The treatment methods such as magnetic hyperthermia, chemotherapy, photothermal therapy and MRI‐traced cancer drug delivery system have been available for cancer treatment. The prime of cancer treatment is Chemotherapy but it has not proved the proper satisfaction due to the resistance developed in the tumour. Now‐a‐days, dendrimers are the most important and powerful drug carriers in the anticancer applications. The polyamidoamine (PAMAM) dendrimers have played wider role and the addition of nanomaterials in polyamidoamine dendrimer provided great results in the anticancer properties and medicinal applications. In recent years, researchers have interested to undergo investigation on dendrimer supported nanomaterials due to the outstanding experimental results against the cancer cells. Therefore, the main goal of the article is to deliberate the comprehensive overview of the properties, anticancer applications of the nanomaterials supported dendrimer as the nanocarrier for the anticancer applications.