The objective of this case report was to investigate whether Candida albicans adhesion to the poly(methyl methacrylate) (PMMA) denture surface is reduced by surface modifications in two innovative methods. Three experimental groups on the tissue surface of a maxillary denture consisted of a control (pure PMMA), negatively surface-charged modified-PMMA (mPMMA), and application of a self-bonding polymer (SBP). The results of the clinical report revealed that both mPMMA and SBP groups had reduced amounts of adherent C. albicans on the resin surfaces compared to the control. Interestingly, the SBP demonstrated a reduced amount of C. albicans adherence up to 21 days followup, where the mPMMA group exhibited a longer effect till 30 days.
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