In this work, we have synthesized Carbon Dots (CDs) through a single-step microwave-assisted method. The synthesized colloidal CDs have narrow size distribution and show excellent optical properties as well as biocompatibility. Folic acid was selected as a carbon precursor to introduce intrinsic folate receptor targeting capabilities of CDs and to achieve high water dispersibility. CDs were characterized by a series of spectroscopic and microscopic techniques followed by anticancer drug Doxorubicin (Dox) conjugation for potential drug release applications. In near-physiological conditions, the drug loading and the release of Dox were investigated in detail. CDs-Dox conjugates are sensitive toward pH and showed efficient drug release as monitored kinetically by fluorescence. Further, live-cell fluorescence imaging using confocal microscopy establishes the pH-responsiveness of the drug release mechanism and cellular uptake mediated by folate receptors. We believe that such biocompatible nanocomposite will be beneficial in cancer treatment.
In the present research work, a carbon-dots (CDs)-based self-assembled drug delivery system for the delivery of doxorubicin in cancer cells was developed. CDs with a narrow size distribution were synthesized...
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