Glucose-derived carbon dots for targeted delivery of doxorubicin in cancer therapy

Dubey, Naveneet; Ramteke, Suman; Jain, Narendra Kumar; Dutta, Tanoy; Koner, Apurba Lal

doi:10.1039/d3nj02843g

Cited by 4 publications

(5 citation statements)

References 68 publications

(82 reference statements)

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“…The synthesized self-assembled conjugates were highly sensitive to an acidic pH and showed improved cytotoxicity toward cervical cancer cells, according to time-dependent rate kinetics and in vitro release assays. 168 For the purpose of treating colorectal cancer, Shivangi Paliwal et al created folic acidconjugated capecitabine-capped passivated carbon dots (CAP-FA-CNDPs). Buchnania lanzan leaf extract was microwavetreated to create carbon dots, and PEG6000 was utilized as a surface passivating agent (Figure 14B).…”

Section: Resultsmentioning

confidence: 99%

“…Positively charged Dox self-assembles on strongly negatively charged CNDs as a result of the conjugation; this process has been seen using a variety of spectroscopic, microscopic, and cellular research methods. The synthesized self-assembled conjugates were highly sensitive to an acidic pH and showed improved cytotoxicity toward cervical cancer cells, according to time-dependent rate kinetics and in vitro release assays . For the purpose of treating colorectal cancer, Shivangi Paliwal et al created folic acid-conjugated capecitabine-capped passivated carbon dots (CAP-FA-CNDPs).…”

Section: Resultsmentioning

confidence: 99%

“…(B) CAP-FA-CNDPs are created by synthesizing CNDs from Buchnania lanzan leaf extract, passivating CNDs, and attaching folic acid (FA) and capecitabine (CAP) to their surfaces. Reproduced with permission from ref . Copyright 2023 Royal Society of Chemistry.…”

Section: Resultsmentioning

confidence: 99%

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Carbon Dots: Synthesis, Characterizations, and Recent Advancements in Biomedical, Optoelectronics, Sensing, and Catalysis Applications

Lamba,

Yukta,

Mondal

et al. 2024

ACS Appl. Bio Mater.

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Carbon nanodots (CNDs), a fascinating carbon-based nanomaterial (typical size 2−10 nm) owing to their superior optical properties, high biocompatibility, and cell penetrability, have tremendous applications in different interdisciplinary fields. Here, in this Review, we first explore the superiority of CNDs over other nanomaterials in the biomedical, optoelectronics, analytical sensing, and photocatalysis domains. Beginning with synthesis, characterization, and purification techniques, we even address fundamental questions surrounding CNDs such as emission origin and excitation-dependent behavior. Then we explore recent advancements in their applications, focusing on biological/biomedical uses like specific organelle bioimaging, drug/gene delivery, biosensing, and photothermal therapy. In optoelectronics, we cover CND-based solar cells, perovskite solar cells, and their role in LEDs and WLEDs. Analytical sensing applications include the detection of metals, hazardous chemicals, and proteins. In catalysis, we examine roles in photocatalysis, CO 2 reduction, water splitting, stereospecific synthesis, and pollutant degradation. With this Review, we intend to further spark interest in CNDs and CND-based composites by highlighting their many benefits across a wide range of applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Carbon Dots: Synthesis, Characterizations, and Recent Advancements in Biomedical, Optoelectronics, Sensing, and Catalysis Applications

Lamba,

Yukta,

Mondal

et al. 2024

ACS Appl. Bio Mater.

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“…2A), a similar effect that was also observed previously in the interaction of CQDs with many compounds. 7,8,11 Various mechanisms, such as static quenching, dynamic quenching, or the inner lter effect, may contribute to these interactions. In order to investigate and analyze the uorescence quenching observed in the presence of gabapentin, additional research was conducted.…”

Section: Sensing Principles Of Gabapentin Based On N-cqdsmentioning

confidence: 99%

“…3,4 These properties make them highly versatile and suitable for numerous applications including bioimaging, drug delivery, tumour diagnosis, catalysis, sensors, and even in cancer therapy. [5][6][7][8][9] Furthermore, carbon quantum dots are known for their low toxicity and low cost of production, making them an attractive alternative to other types of quantum dots such as semiconductor quantum dots or commercial organic dyes. 10 The synthesis of carbon quantum dots can be achieved through two main methods: the "top-down" method and the "bottom-up" method.…”

Section: Introductionmentioning

confidence: 99%

Efficient and eco-friendly detection of gabapentin using nitrogen-doped carbon quantum dots: an analytical and green chemistry approach

Almalki,

Abdelazim,

Alosaimi

et al. 2024

RSC Adv.

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Synthesis of flexible magneto‐electric polyvinyl alcohol composites using hybrid filler particles of carbon quantum dots and cobalt nano for electromagnetic interference shielding application

Suresh,

Kandavalli,

Rajendiran

et al. 2024

Vinyl Additive Technology

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The main objective of the study is to synthesis and characterization of flexible magneto‐electric Polyvinyl Alcohol (PVA) composites for Electromagnetic Interference (EMI) shielding applications, by incorporating carbon quantum dots extracted from lychee fruit husks and cobalt nanoparticles sourced from Plectranthus amboinicus. Comprehensive mechanical, dielectrical, magnetic, and shielding tests were conducted to assess the performance of these novel materials. The mechanical characteristics of the composites were assessed to gauge their flexibility and robustness. In this regard, PV4 displayed a substantial tensile strength of 68 MPa, while PV6 exhibited an enhanced shore‐D hardness rating of 47. PV6 demonstrates superior dielectric properties, including a higher dielectric constant and a lower loss tangent, which are crucial for optimizing EMI shielding efficiency. When it comes to magnetic characteristics such as magnetization, retentivity, and coercivity, the PV6 composite designation outperforms the other composites. Additionally, PV6 exhibits higher electromagnetic interference (EMI) shielding effectiveness, measuring at approximately 49.8 dB in the E band and 56.5 dB in the F band. Findings demonstrate that the integration of carbon quantum dots and cobalt nanoparticles into the matrix resulted in flexible composites with enhanced mechanical strength. The incorporation of cobalt contributed to notable magnetic properties, increasing the materials' magnetization and retentivity. The tests on electromagnetic interference (EMI) showed that the shielding effectiveness got improved. The composite materials were able to reduce interference from electromagnetic waves in the tested frequency ranges. These flexible magneto‐electric PVA composites, developed using sustainable sources such as lychee fruit husks and Plectranthus amboinicus, exhibit promising potential for EMI shielding applications in diverse industries, including telecommunications, aerospace, and electronics, where reliable interference control is essential for optimal performance and safety.Highlights Cobalt nanoparticles sourced from Plectranthus amboinicus. Carbon quantum dots are prepared from lychee fruit husks via controlled pyrolysis. High tensile strength PVA composites prepared. Highest dielectric constant of 8.2 achieved for composite PV6. Higher wave shielding up to 56.5 dB achieved in “E” band.

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Glucose-derived carbon dots for targeted delivery of doxorubicin in cancer therapy

Abstract: In the present research work, a carbon-dots (CDs)-based self-assembled drug delivery system for the delivery of doxorubicin in cancer cells was developed. CDs with a narrow size distribution were synthesized...

Cited by 4 publications

References 68 publications

Carbon Dots: Synthesis, Characterizations, and Recent Advancements in Biomedical, Optoelectronics, Sensing, and Catalysis Applications

Carbon Dots: Synthesis, Characterizations, and Recent Advancements in Biomedical, Optoelectronics, Sensing, and Catalysis Applications

Efficient and eco-friendly detection of gabapentin using nitrogen-doped carbon quantum dots: an analytical and green chemistry approach

Synthesis of flexible magneto‐electric polyvinyl alcohol composites using hybrid filler particles of carbon quantum dots and cobalt nano for electromagnetic interference shielding application

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