Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease with common cognitive deficits and potential brain involvement in addition to the cardinal muscular and systemic symptoms. Impaired mental function associated with nonspecific pathological findings such as white-matter hyperintense lesions (WMHLs), ventricular enlargement and brain atrophy on brain MRI have been previously reported in DM1 patients. While some studies showed correlation of brain morphological changes with neuropsychological and clinical parameters including CTG repeat sizes and disease severity scales in DM1, others failed. The goal of this study was to retrospectively investigate cranial MR abnormalities, predominantly WMHLs, and their effects on clinical and cognitive deficits in a small, phenotypically or genotypically well-characterized cohort of DM1 patients.
We did not observe any changes in interventricular foramina or cerebral aqueduct measurements in healthy subjects from a wide range of age groups. Such changes should be useful for diagnosing diseases that affect the ventricular system and planning surgical procedures, especially those involving the ventricular system.
ÖzetUçak yolculuğu ile ilişkili başağrısı, son yıllarda olgu sunumlarıyla önem kazanmış ve 2013 yılında başağrısı sınıflamasında yerini almıştır. Bu nadir durum primer başağrılarından farklı özel karakteristik özelliklere sahiptir ve patofizyolojisi henüz net değildir. Bu olguda, 27 yaşındaki bir kadın hastaya anamnez, muayene ve görüntüleme yöntemleriyle uçak yolculuğu ile ilişkili başağrısı tanısı konuldu. Literatür eşliğinde muhtemel patofizyolojisi ve tedavisi tartışıldı.Anahtar sözcükler: Naproksen sodyum; sinüs barotravması; uçak yolculuğu başağrısı.
SummaryRecently, headache associated with airplane travel has gained importance with case reports and took its place in the classification of headache in 2013. This rare condition has different spesific characteristic from the primary headaches and its pathophysiology is not clear yet. In this case report, a 27-years-old female patient was diagnosed with the headache associated with airplane travel by history, examination and imaging findings. The possible pathophysiology and treatment were discussed.
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