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Laboratory evaluations were made to assess the toxicological and biochemical effect of cypermethrin on fingerlings of common edible freshwater culture carp (Labeo rohita). There was a significant negative (P < 0.05) correlation observed between effective doses of cypermethrin and exposure periods; that is, LC50 values decreased from 0.323 μg/L (6 h) to  > 0.278 μg/L (12 h),  > 0.240 μg/L (18 h) and >0.205 μg/L (24 h). Exposure to sublethal doses of cypermethrin for 24 h and 96 h exposure period caused significant (P < 0.05) time- and dose-dependent alterations in total protein, total free amino acids, nucleic acids, glycogen, pyruvate, and lactate level and in the activity of enzyme protease, alanine aminotransferase, aspartate aminotransferase, acid phosphatases, alkaline phosphatases, acetylcholinesterase, and cytochrome oxidase in liver and muscle tissues of fish. Thus, cypermethrin has potent piscicidal activity against fingerlings of fish Labeo rohita and adversely affects their behavioural patterns, shifting aerobic pathway of fish respiration towards anaerobic pathway and also inhibiting energy production by suppressing ATP synthesis.

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We report the results of our optical (VRI) photometric observations of the TeV blazar 1ES 0806+524 on 153 nights during 2011-2019 using seven optical telescopes in Europe and Asia. We investigated the variability of the blazar on intraday as well as on long-term timescales. We examined eighteen intraday light curves for flux and color variations using the most reliable power-enhanced F-test and the nested ANOVA test. Only on one night was a small, but significant, variation found, in both V band and R band light curves. The V − R color index was constant on every one of those nights. Flux density changes of around 80% were seen over the course of these eight years in multiple bands. We found a weighted mean optical spectral index of 0.639±0.002 during our monitoring period by fitting a power law (F ν ∝ ν −α ) in 23 optical (V RI) spectral energy distributions of 1ES 0806+524. We discuss different possible mechanisms responsible for blazar variability on diverse timescales.

Cycloart-24-en-3β-ol isolated from Euphorbia royleana latex possesses potent piscicidal activity against freshwater predatory fish Channa punctatus. Their short as well as long-term exposure causes significant (P<0.05) time and dose-dependent reversible alteration in the oxidative metabolism of the fish Channa punctatus Cycloart-24-en-3β-ol also shifts fish respiratory pathway, inhibits energy production and AChE activity reversibly may be advantageous for their use as environmentally safe piscicide for controlling the predatory fish C. punctatus population from carp culture ponds.

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