When gel and emulsion are mixed to make a dose, it is referred to as an Emulgel. Emulgel is one of the most exciting topical administration systems owing to its dual type of release control mechanism. The fundamental aim of this formulation is to transfer hydrophobic medication to the systemic circulation through the skin. Emulgel are essentially just water-based emulsions that have gone through a gelling process. The dermatological Emulgel is non-staining, water-soluble, emulsifying, thixotropic, simple to spread, easy to remove, thixotropic and environmentally friendly. Penetration enhancers may be used to increase the efficacy of a product. Consequently, it might be a more effective method of delivering topical medications than the current methods in use. It has become clear that Emulgel is an excellent delivery mechanism for hydrophobic compounds. Carbopol 934, a gelling chemical, was used in this study to create calendula oil Emulgel. Essential oils like clove and mentha were utilised to increase penetration. Afterward, the gel formulation was poured over the emulsion and allowed to harden. Rheological tests, spreading coefficient testing, and in vitro release investigations were conducted on Calendula oil topical Emulgel to determine their sun protection factor. Exfoliative cheilitis may be treated with calendula oil Emulgel applied to the skin.
This review assesses the use of Calendula officinalis extract in antihyperlipidemic activities, cardiovascular activities, antidiabetic, hepatoprotective activities; anthelmintic activities; antioxidant activities; anti-inflammatory activities; wound healing activities; anticancer activities; hepatoprotective activities, antibacterial activities; and anti-HIV activities. C. officinalis extract has been shown to have some remedial effects and has been used in herbal remedies, according to this review. To examine the effect of calendula officinalis, larger as well as well-designed random control trials are needed. Calendula officinalis is a flowering plant that comes under the Asteraceae family. This herb is used as curative in Europe, China, and India. It's been the subject of a number of chemical and pharmacological research, and it's also known as "African marigold." It's commonly utilized in indigenous medicine to treat jaundice, wound recovery, plasma cleansing, and spasmolytic treatment. A vast range of chemicals, including amino acids, triterpenoids, coumarines, quinones, flavonoids, volatile oils, and carotenoids, have been found through chemical analysis.
The present study aimed to evaluate effects of Bryophyllum Pinnatum extract on calcium oxalate and calcium phosphate by in vitro methods. The leaves of Bryophyllum Pinnatum were sequentially extracted by using the hot maceration method, with a solvent such as ethanol, water and hydroalcoholic solution in various concentrations. The obtained extract was subjected to phytochemical screening and the test for alkaloid, flavonoid, saponin, phenol and triterpenoid saponin. For the in vitro study, experimentally calcium phosphate and calcium oxalate stones were prepared and compared with standard drug. Cystone is used as standard drugs. Bryophyllum Pinnatum is rich in phytochemicals such as alkaloids, saponin, glycoside, kamferol, and flavonoids and has a substantial capacity to dissolve calcium phosphate and calcium oxalate. These flavonoids inhibit calcium Phosphate and calcium oxalate deposits from forming in the renal tubules. The leaf extract contains anti-urolithiasis therapy and preventative capabilities and lowers the size of stones. In addition to diuretic and antiurolithic, antidiabetic, anticancer, anti-ulcer, anti-microbial, and wound healing activities, Kalanchoe pinnata leaf extract includes phenolic chemicals, tannin, and titerpenes. The main goal of the study is to find out how the Bryophyllum Pinnatum herb, especially its leaves, can prevent and treat health problems like renal stones, which are becoming more common in younger people because they don't exercise and eat poorly. The ability of the extract to get small particles out of the kidney and out of the urinary tract reduces the chance that they will get stuck in the urinary tract and form stones.
The plants of Carica papaya are utilised for nutritional and therapeutic purposes. The phytochemical examination of the leaf extract of Carica papaya reveals all phytochemical elements, including saponin, flavonoid, glycoside, alkaloid, carbohydrates, tannins, and steroids. A systematic phytochemical analysis was used to check all extracts for the presence of phytochemical components. Free radical scavenging; wound healing; neuroprotection; diuretic; abortifacient; antifertility; anti-sickling; neuroprotective; diuretic; abortifacient; Antimicrobial properties of papaya seed extracts have been shown to be effective against B. cereus, S. faecalis, S. aureus, and a variety of bacterial pathogens. Anti-inflammatory properties of an ethanolic extract of Carica papaya L. leaf were investigated in rats with paw oedema. In order to create the extract, many solvents were used such as alcohol, methanol, and ethanol as well as aqueous extracts such as acetone and chloroform. The research indicates that the latex of papaya fruits exhibits substantial efficacy against Candida albicans. The well diffusion approach inhibits S. aureus more effectively than E. coli when using methanol extract. It has antifungal, antibacterial, anti-inflammatory, antioxidant, anti-diabetic, wound-healing, and analgesic properties, among others. According to the findings of this investigation, when given in doses of 50, 75, and 100 mg/ml, Carica papaya leaf extract had more antifungal activity against Colletotrichum gloeosporioides than Fusarium spp., Rhizopus stolonifer, and antibacterial activity than aqueous papaya leaf extract.
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