Structural insight of the protein–protein interaction (PPI) interface can provide knowledge about the kinetics, thermodynamics and molecular functions of the complex while elucidating its role in diseases and further enabling it as a potential therapeutic target. However, owing to experimental lag in solving protein–protein complex structures, three-dimensional (3D) knowledge of the PPI interfaces can be gained via computational approaches like molecular docking and post-docking analyses. Despite development of numerous docking tools and techniques, success in identification of native like interfaces based on docking score functions is limited. Hence, we employed an in-depth investigation of the structural features of the interface that might successfully delineate native complexes from non-native ones. We identify interface properties, which show statistically significant difference between native and non-native interfaces belonging to homo and hetero, protein–protein complexes. Utilizing these properties, a support vector machine (SVM) based classification scheme has been implemented to differentiate native and non-native like complexes generated using docking decoys. Benchmarking and comparative analyses suggest very good performance of our SVM classifiers. Further, protein interactions, which are proven via experimental findings but not resolved structurally, were subjected to this approach where 3D-models of the complexes were generated and most likely interfaces were predicted. A web server called Protein Complex Prediction by Interface Properties (PCPIP) is developed to predict whether interface of a given protein–protein dimer complex resembles known protein interfaces. The server is freely available at http://www.hpppi.iicb.res.in/pcpip/.
AJSTjJACTRadiation blistering in solids has been identified as a process leading to damage and erosion of irradiated surfaces. Sonic-of the major parameters governing the blistering process in metals and sonse metallic alloys are the type of projectile and its energy, total dose, dose rate, target temperature, channeling condition of the projectile, orientation of che irradiated surface plane, and target material and its isicrostrueture. This paper reviews both experimental results and models proposed for blister formation and rupture. The blistering paenomenon is important as an erosion process in applications such as fusion reactor technology (plasma-wall interactions) And accelerator technology (erosion of components and targets).The review includes a description of methods for the reduction of surface erosion causad by blistering.
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