Objective: The purpose of the present study was to functionalized graphene (f-GE) grafted chitosan (CS)/Polyaniline (PANI) with Montmorillonite (MMT) was different feed ratio known as f-GE-g-(CS/MMT-PANI). Methods: The prepared f-GE-g-(CS/MMT-PANI) was formulated using the solvent casting method. The prepared nanocomposites were characterized by X-Ray Diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), Thermogravimetric analysis (TGA), thermogravimetric (DTG) and swelling in stimulated in the different biological fluid. The model drug Doxorubicin (DOX) was used for controlled drug delivery purpose. Results: From FTIR result was clearly demonstrated that the model drug DOX did not change in any molecular level at f-GE-(CS/MMT-PANI) (i.e. at<10 nm scale). Additionally, in DSC result, DOX was interacted with nanocomposites at scale>100 nm level. With CS as the carrier, 60% of the drug was released in SIF for the initial 120 min and this increased to 80–82% with f-GE-g-CS/MMT/PANI matrix. But in SGF, CS as the carrier, 46% of the drug was released in 140 min and this increased to 78% with f-GE-g-CS/MMT/PANI. In vitro drug release system was carried out by Korsmeyer Peppas’s power law. DOX and other drugs like Doxorubicin (DOX) was presented an exceptional higher drug result in different pH medium. Conclusion: It was observed that CS/MMT was decreasing less drug release rate compared to f-GE-g-(CS/MMT-PANI). So that it can be clearly understood that f-GE-g-(CS/MMT-PANI) grafted nanocomposites have enhanced drug release activity in different pH medium.
In this study chitosan nanoparticles (CSNPs) coated functionalized graphene-gold nanoparticles (F-GE-AuNPs) known as (CSNPs-F-GE/AuNPs). The prepared nanocomposites were characterized by UV-Visible spectrophotometer, XRD, FTIR, SEM, tensile strength and swelling in stimulated in different phosphate buffer medium. The model anticancer drug Vincristine (VIS) was used for controlled drug delivery purpose. From FTIR result was clearly demonstrated that the model drug VIS did not change in any molecular level at CSNPs-F-GE/AuNPs. In vitro drug release system was carried out .VIS was presented exceptional higher drug result in different pH medium. It was observed that CSNP and F-GE/AuNPs was decrease less drug release rate compared to CSNPs-F-GE/AuNPs. So that it can be clearly understood that CSNPs-F-GE/AuNPs nanocomposites have enhanced drug release activity in different pH medium.
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