Androgens affect several human skin and prostate functions, and the androgen receptor is crucial for regulating the androgen-related mechanisms. In this study, we assessed the antagonizing effects of a Scutellaria baicalensis extract and its main component baicalin on proliferation of human scalp dermal papilla cells. First, the extract and baicalin slightly dissociated the radioisotope-labeled androgen receptor-agonist complex in the androgen receptor binding assay, and the IC50 values were measured to assess the androgen receptor antagonistic effect of the extract (93 µg/mL) and baicalin (54.1 µM). Second, the extract and baicalin treatments dose-dependently inhibited the overgrowth of LNCaP prostate cancer cells, which were stimulated by dihydrotestosterone. Third, the extract and baicalin inhibited nuclear translocation of the androgen receptor stimulated by dihydrotestosterone in human dermal papilla cells. Additionally, the extract and baicalin enhanced proliferation of human dermal papilla cells in vitro. These results show that the extract and baicalin inhibited androgen activation signaling and promoted hDPC proliferation, suggesting that they could be used as active ingredients for treating androgen-associated disorders, such as androgenetic alopecia.
With the exception of conditions such as dandruff, interest in the scalp is relatively low. However, when we consider the scalp as part of the skin, interesting observations can be made. The average amount of sebum secretion in the scalp varies depending on sex. Several studies show differences in scalp characteristics among races, but in some cases, these are difficult to find. The scalp has a weaker barrier function than does facial skin. The reason for the weak barrier function is unclear, but it is necessary to consider the effect of dandruff on the scalp. Growth of dandruff-related bacteria weakens the barrier. However, strengthening the barrier suppresses dandruff. In other words, there is an interdependency between scalp bacteria and skin, which is important for the maintenance of scalp barrier homeostasis. Anxiety regarding a sensitive scalp is as high as that for sensitive skin. At least 40% -50% of individuals in modern society have complaints such as itching due to a sensitive scalp. The sensitivity of the scalp is similar between races. This is not a skin disease, but we have to think about how problems that customers face can be solved. Skin barrier and sensitive scalp are closely related. Collectively, strengthening or lowering the effect on the scalp barrier may result in a healthy scalp environment. As a result, it will alleviate people's complaints about the scalp.
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