The Inhibitory Effect of Scutellaria baicalensis Extract and Its Active Compound, Baicalin, on the Translocation of the Androgen Receptor with Implications for Preventing Androgenetic Alopecia

Kim, Ahreum; Kim, Su-Na; Jung, In Keun; Kim, Hyun-Hee; Park, Young-Ho; Park, Won-Seok

doi:10.1055/s-0033-1360300

Cited by 36 publications

(31 citation statements)

References 15 publications

(17 reference statements)

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“…[1][2][3] In recent years, a large number of pharmacological studies have shown that flavonoids were the main active constituents in S. baicalensis. [3][4][5] At present, more than 60 flavonoids have been isolated from S. baicalensis and identified.…”

Section: Introductionmentioning

confidence: 99%

Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes

Wei

Guo

Zheng

et al. 2014

IJN

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Baicalin (BA) is a major constituent of Scutellaria baicalensis Georgi , a medicinal herb. Previous pharmacokinetic studies of BA showed its low oral bioavailability. The aim of the present study was to develop a novel BA-loaded liposome (BA-LP) to enhance oral bioavailability. BA-LP, composed of BA, Tween ® 80, Phospholipon ® 90H, and citric acid at weight ratio of 96/50/96/50, respectively, was prepared by the effervescent dispersion technique and characterized in terms of morphology, size, zeta potential, encapsulation efficiency, and the in vitro release. Pharmacokinetics and biodistribution studies were carried out in rats after oral administration of BA-LP and a carboxymethyl cellulose suspension containing BA (BA-CMC) as a control. BA-LP exhibited a spherical shape by transmission electron microscopy observation. BA-LP had a mean particle size of 373±15.5 nm, zeta potential of −20.1±0.22 mV, and encapsulation efficiency of 82.7%±0.59%. The BA-LP showed a sustained-release behavior, and the in vitro drug-release kinetic model fit well with the Weibull distribution equation: lnln (1/(1−Q)) =0.609 lnt −1.230 ( r =0.995). The oral bioavailability and the peak concentration of the BA-LP was threefold and 2.82-fold that of BA-CMC, respectively. The in vivo distribution results indicated that drug concentrations were significantly increased in the liver, kidney, and lung in the case of BA-LP, which were 5.59-fold, 2.33-fold, and 1.25-fold higher than those of BA-CMC, respectively. In conclusion, the study suggested that BA-LP might be a potential oral drug delivery system to improve bioavailability of BA.

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Section: Introductionmentioning

confidence: 99%

Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes

Wei

Guo

Zheng

et al. 2014

IJN

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“…As a result, researchers have been exploring various promoting agents for SCs proliferation, such as interleukin-1β (14) and tanshinone IIA (15 Utilizing plant-derived traditional Chinese medicines to treat various types of diseases has a long history in East Asian countries, such as China, Korea and Japan (16). Furthermore, some western medicines are derived from major constituent of traditional Chinese medicine (17) Scutellaria baicalensis Georgi (Huangqin in Chinese), a traditional Chinese medicine, has been used to treat inflammation, fever, ulcers and cancer for hundreds of years (18)(19)(20) and a recent study has reported that flavonoids from the stems and leaves of S. baicalensis Georgi have neuroprotective effects (21). Baicalin, one of the major flavonoid isolated from the root of S. baicalensis, has a variety of biological functions, including anti-inflammatory, anti-oxidant and anti-apoptotic activities (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Baicalin promotes the viability of Schwann cells in vitro by regulating neurotrophic factors

Zuo

Zhang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The proliferation and migration of Schwann cells (SCs) are key events in the process of peripheral nerve repair. This is required to promote the growth of SCs and is a challenge during the treatment of peripheral nerve injury. Baicalin is a natural herb-derived flavonoid compound, which has been reported to possess neuroprotective effects on rats with permanent brain ischemia and neuronal differentiation of neural stem cells. The association of baicalin with neuroprotection leads to the suggestion that baicalin may exert effects on the growth of SCs. In the present study, the effects of baicalin on SCs of RSC96 were investigated. RSC96 SCs were treated with various concentrations of baicalin (0, 5, 10 or 20 µM) for 2, 4 and 6 days. Cell attachment, viability and gene expression were monitored via the MTT assay and reverse transcription-quantitative polymerase chain reaction. The gene expression levels of several neurotrophic factors, such as glial cell-derived neurotrophic factor, brain-derived neurotrophic factor and ciliary neurotrophic factor, which are considered important factors in the process of never cell regeneration, were detected. The results indicated that baicalin was able to promote the viability of RSC96 SCs in a dose-dependent manner and the concentration of 20 µM of baicalin exhibited the greatest cell viability and gene expression of the studied neurotrophic factors. The present findings suggested that baicalin likely affects SCs metabolism, through modulating the expression of neurotrophic factors. To conclude, the present study indicates that baicalin may be potential therapeutic agent for treating peripheral nerve regeneration.

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“…It has many pharmaceutical actions such as anti-inflammatory action, antibiotic action, antioxidant properties, and antiproliferative effects on prostate cancer cells. Further, Baicalin antagonises the androgen receptor by suppressing the dihydrotestosterone dependent activation cascade and also promotes proliferation of the human papillary dermal cells [5]. Baicalin activates Wnt/βcatenin signaling in a dose dependent manner in human dermal papilla cells.…”

Section: Discussionmentioning

confidence: 95%

A Study to Evaluate the Efficacy of Baicapil Formulations in Treatment of Telogen Effluvium

2018

IJCED

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Introduction:The changes in lifestyle and food habits have resulted in a steady increase in number of people presenting with hair loss and poses quite a challenge for dermatologists. Baicalin is an active flavonoid which activates dermal papilla cells & induces the mRNA expression of growth factors, such as insulin like growth factor 1 (IGF1) and vascular endothelial growth factor (VEGF). This action can clinically transform the telogen phase to anagen phase due to which there is good scope of using this product in telogen effluvium. Materials & Methods:This was a pilot study on 30 subjects who had persistent hair loss for more than 3 months. Subjects were directed to apply 1ml (6 sprays) of the anti hair loss serum containing Baicapil in the morning after bath & once before bed time for 2 months. Efficacy of the hair serum was assessed using subjective scale and objective method at baseline, day 30 and day 60. Results:In our study 63.3% of subjects had persistent hair loss of more than 6 months duration. Majority of our subjects belonged to the age group of 21 to 25 years with mean age of 26.33 ± 8.7 years and 46.7% were students. In the study median subjective score at 1st visit was 7, at 2 nd visit score reduced to 6 and at 60 th day score reduced to 4 which is statistically significant (p=<0.001). With respect to objective assessment at Point A, median number of thin hairs at 1 st visit was 6, at 2 nd visit it reduced to 4 and at 3 rd visit reduced to 3. With respect to Objective assessment in Point B, median number of thin hairs at 1st visit was 5, at 2 nd visit reduced to 3 and at 3 rd visit reduced to 2 which was also statistically significant(p=<0.001). Conclusion:Baicapil formulations are effective in decreasing hair loss and promoting hair growth in case of patients with telogen effluvium. Volume 3 | Issue 2 | 1 of 5

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The Inhibitory Effect of Scutellaria baicalensis Extract and Its Active Compound, Baicalin, on the Translocation of the Androgen Receptor with Implications for Preventing Androgenetic Alopecia

Cited by 36 publications

References 15 publications

Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes

Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes

Baicalin promotes the viability of Schwann cells in vitro by regulating neurotrophic factors

A Study to Evaluate the Efficacy of Baicapil Formulations in Treatment of Telogen Effluvium

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