The growing complexity of customizable single-chip multiprocessors is requiring communication resources that can only be provided by a highly-scalable communication infrastructure. This trend is exemplified by the growing number of network-on-chip (NoC) architectures that have been proposed recently for system-on-chip (SoC) integration. Developing NoC-based systems tailored to a particular application domain is crucial for achieving high-performance, energy-efficient customized solutions. The effectiveness of this approach largely depends on the availability of an ad hoc design methodology that, starting from a high-level application specification, derives an optimized NoC configuration with respect to different design objectives and instantiates the selected application specific on-chip micronetwork. Automatic execution of these design steps is highly desirable to increase SoC design productivity. This work illustrates a complete synthesis flow, called Netchip, for customized NoC architectures, that partitions the development work into major steps (topology mapping, selection, and generation) and provides proper tools for their automatic execution (SUNMAP, xpipescompiler). The entire flow leverages the flexibility of a fully reusable and scalable network components library called xpipes, consisting of highly-parameterizable network building blocks (network interface, switches, switch-to-switch links) that are design-time tunable and composable to achieve arbitrary topologies and customized domain-specific NoC architectures. Several experimental case studies are presented In the work, showing the powerful design space exploration capabilities of the proposed methodology and tools

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ObjectiveThe aim of this study was to evaluate the correlation between the various NOTCH3 mutations and their clinical and genetic profile, along with the presentation of a novel mutation in a patient.MethodsHere, we describe the phenotype of a patient with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) harboring a novel mutation. We also performed an extensive literature research for NOTCH3 mutations published since the identification of the gene and performed a systematic review of all published cases with NOTCH3 mutations. We evaluated the mutation pathogenicity in a great number of patients with detailed clinical and genetic evaluation and investigated the possible phenotype-genotype correlations.ResultsOur patient harbored a novel mutation in the NOTCH3 gene, the c.3084 G > C, corresponding to the aminoacidic substitution p.Trp1028Cys, presenting with seizures as the first neurologic manifestation. We managed to find a correlation between the pathogenicity of mutations, severity of the phenotype, and age at onset of CADASIL. Significant differences were also identified between men and women regarding the phenotype severity.ConclusionsThe collection and analysis of these scarce data published since the identification of NOTCH3 qualitatively by means of a systematic review and quantitatively regarding genetic profile and pathogenicity scores, highlight the significance of the ongoing trend of investigating phenotypic genotypic correlations.