Previous research has suggested that vegetarianism may serve as a mask for restrained eating. The purpose of this study was to compare the dietary habits and lifestyle behaviors of vegetarians (n=55), pesco-vegetarians (n=28), semi-vegetarians (n=29), and flexitarians (n=37), to omnivores (n=91), who do not restrict animal products from their diets. A convenience sample of college-age females completed questionnaires about their eating habits, food choice motivations, and personality characteristics. Results indicated that while vegetarians and pesco-vegetarians were more open to new experiences and less food neophobic, they were not more restrained than omnivores. Rather semi-vegetarians; those who restricted only red meat from their diet, and flexitarians; those who occasionally eat red meat, were significantly more restrained than omnivores. Whereas food choices of semi-vegetarians and flexitarians were motivated by weight control, vegetarians and pesco-vegetarians' food choices were motivated by ethical concerns. By focusing specifically on semi-vegetarian and flexitarian subgroups, more effective approaches can be developed to ensure that their concerns about weight loss do not lead to unhealthful or disordered eating patterns.
We have identified several series of small molecule inhibitors of TrkA with unique binding modes. The starting leads were chosen to maximize the structural and binding mode diversity derived from a high throughput screen of our internal compound collection. These leads were optimized for potency and selectivity employing a structure based drug design approach adhering to the principles of ligand efficiency to maximize binding affinity without overly relying on lipophilic interactions. This endeavor resulted in the identification of several small molecule pan-Trk inhibitor series that exhibit high selectivity for TrkA/B/C versus a diverse panel of kinases. We have also demonstrated efficacy in both inflammatory and neuropathic pain models upon oral dosing. Herein we describe the identification process, hit-to-lead progression, and binding profiles of these selective pan-Trk kinase inhibitors.
Two subspecies of Black Rail Laterallus jamaicenis occur in the United States, and neither has been studied extensively. Of the two, the Eastern subspecies L. j. jamaicenis has a larger range, but has been studied to a lesser degree than the California subspecies (L. j. coturniculus Eastern Black Rail are known to breed at several locations in Kansas, but as in other inland populations, precisely where these individuals overwinter is unknown. Additionally, little information is available on characteristics of breeding habitat for inland Eastern Black Rail populations, and few studies have investigated the effect of habitat management techniques on these populations. Eastern Black Rail are rnost often observed in Kansas at Quivira National Wildlife Refuge NWR and private lands surrounding it. Call playback surveys were conducted in the summers of 2009 and 2010 to locate breeding individuals and identify nesting habitat. Drift-fences and traps were set in locations where individual Black Rail were detected, and sound samples were used to attract individuals for capture. Rectrices and body coverts were plucked from similar regions on two captured individuals and used for deuterium stable isotope analysis. Coverts had average deuterium values of -86.2 and -77.8 per mil, respectively. These values are more typical for southern Canada and portions of the western United States. These feather values suggest that Kansas occurring Black Rail either winter away from the Gulf Coast, in contrast to current understanding, or grow feathers during or soon after spring migration. Quivira NWR and surrounding private lands use prescribed burning, grazing and haying to manage vegetation in the wet-meadow habitat that the rails typically occupy. To characterize breeding habitat, I quantified vertical vegetation structure, water presence and depth, and plant height in areas where Black Rail responded during playback surveys. A Kruskal-Walis one-way analysis of variance was used to compare these variables among 13 treatment types. Although test results indicated these variables were significantly different among treatment types, a nonparametric Tukey's post-hoc test could not detect where the differences occurred. A backward stepwise (Wald) logistic regression indicated higher percentages of dead vegetation in upper vertical layers and plant height positively influenced rail presence, whereas a higher percentage of living vegetation at lower layers negatively influenced rail presence (Nagelkerke R Square 0.57, p < 0.001). Black Rail were most often detected in sections witl1 moderate levels of disturbance (e.g., burned annually, burned and grazed), while areas with higher levels of disturbance ( e.g., annual haying, haying and burning) did not appear to possess suitable habitat, as no rails were detected in these locations. J:vloderately disturbed areas, such as those burned every two years, might contain the mosaic of living and dead vegetation necessary for Black Rail nesting habitat in this portion their breeding range.
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