Introduction: The cardiac muscle cell, also called the cardiomyocyte, has specialized functions, playing a fundamental role in maintaining life, since it is responsible for the electrical and contractile activity of the heart. Like other specialized cells, it does not have an effective capacity for regeneration and its death or apoptosis is always an undesirable event, with sometimes catastrophic consequences, such as in Heart Failure (HF), which is known as the "final path" of heart diseases. Howe-Conditioned medium of sympathetic ganglia with addition of fibroblast growth factor 2 promotes plasticity of cardiomyocytes in culture
Introduction: Studies show that p-wave dispersion and left atrial ejection fraction are predictors of cardiovascular events. Purpose: To verify the association of p-wave dispersion and left atrial ejection fraction with cardioembolic ischemic stroke. Methods: This is an observational, cross-sectional, case-control study with 61 patients, mean age of 65.6, with sinus rhythm ischemic stroke who underwent clinical evaluation with CHA2DS2-VASc score, electrocardiogram, echocardiogram and ultrasonography with Doppler of both carotid and vertebral arteries. The groups were divided into cardioembolic (cases) and non-cardioembolic (controls). The p-wave dispersion was obtained with a 12-lead electrocardiographic tracing at 50 mm/s by subtracting the largest p-wave by the smallest one. Left atrial ejection fraction was obtained using the modified biplane Simpson method. This study was approved by the UERN Research Ethics Committee (# 2,536,483). Results: Mean values for p-wave dispersion were 62.5 ms for cases and 49 ms for controls (p = 0.025). For left atrial ejection fraction, the cases presented a mean of 42.9% and the controls a mean of 55.8% (p = 0.003). For the CHA2DS2-VASc score, the mean values were 3.6 and 3.1 for cases and controls, respectively (p = 0.35). Cardiovascular risk factors showed similar distribution in both groups. Conclusion: p-wave dispersion and left atrial ejection fraction were associated with the cardioembolic patients with sinus rhythm that have gone through ischemic stroke.
The fibers in the peripheral nervous system are frequent targets of injuries, being distributed throughout the length of the body. Such lesions culminate in motor, sensory and autonomic changes, thus recent evidence shows the influence ideal environment for growth of nerve fibers damaged in the Central Nervous System (CNS). Our objective was to verify this cell behavior in the central sphere, analyzing cellular plasticity of the spinal cord (SC) in the presence of sciatic nerve-conditioned medium (SNCM) from neonatal rats. 12 animals were used, 06 of those aged 45 days, and the other 06 aged 02 days, and it was Sciatic nerve-conditioned medium promotes trophic induction in spinal cord cultured cells
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