ABSTRACT.Purpose: To evaluate whether a significant age-related thinning of the retinal nerve fibre layer (RNFL) is measurable by means of scanning laser polarimetry with variable corneal compensation (GDx-VCC) in a sample of healthy eyes. Methods: A sample of 324 eyes of 324 healthy subjects (mean age 56 ± 14 years, range 21-85 years) underwent a complete ophthalmic evaluation, standard automated perimetry and RNFL scan with the GDx-VCC. Temporal-superior-nasal-inferior-temporal (TSNIT), superior and inferior average (SA and IA) values provided on the printout were collected and their mean value averaged from all eyes and also after separating the eyes by gender and by age decades. The values of the three parameters were plotted against age and linear regression was calculated. Results: Ageing is associated with a significant RNFL thinning (0.08 l, 0.16 l and 0.12 l per year for TSNIT, SA and IA, respectively; p < 0.001). Analysis showed a similar association with age decade (p < 0.001 on anova). For the TSNIT average, a 9.5% thinning from baseline values was estimated for a 65-year lifespan. Corresponding values for SA and IA were 16.2% and 11.7%, respectively. Conclusions: Analysis by GDx-VCC confirmed previous reports about significant age-related RNFL thinning. However, a lower rate per year was found, probably because GDx-VCC measurements are much more reliable than those obtained with the previous generation of polarimeters.

Previous research about the maturation of the smooth pursuit system has been carried out in newborns and in human infants in the first months of life. A lower gain was found with respect to adults (where gain is close to 1), with frequent saccadic intrusions. On the contrary, no data are available about smooth pursuit response in children. To fill this gap, we analyse in this study the level of maturation reached by children over 7 yr old (the minimum age in which a correct test can be done). Using a cosinusoidal stimulation, the smooth pursuit characteristics (velocity and position gains and phases) evaluated in children are compared to the corresponding parameters in adults. Our data show a clear difference between the two groups, in particular for velocity gain values (which are lower in children), and a larger variability in children. Since the influence of fatigue and prediction appears to be small, we conclude that these differences can be justified both by high level psychological or cognitive factors and incomplete maturation of smooth pursuit system in children.

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