Chiral sulfoxides are used as a toolbox for the synthesis of enantiomeric/diastereomeric compounds, which are used as precursors for the pharmaceutically/chemically important molecules. The current review focuses on applying these chiral sulfoxides towards the synthesis of the compounds having stereogenic center. In general, the stereogenic center induced by the sulfoxide is able to direct the stereochemistry of further transformation necessary to complete the total synthesis of bioactive molecules. The nature of the reactive conformation of the sulfoxide is strongly dependent on the nature of the substituents at C-α and/or C-β.
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