The present study depicts the development of a validated RP-HPLC method for the determination of the Levetiracetam in pharmaceutical tablet dosage form. RP-HPLC method was developed by utilizing Welchrom C18 Column (250 x 4.6 mm, 5µ), Shimadzu LC-20AT Prominence Liquid Chromatograph. The mobile phase composed of 10 mM Phosphate buffer: acetonitrile (50:50 v/v) (pH-3.0, adjusted with triethylamine). The flow rate was set to 1.0 ml/min with the responses measured at 243.2 nm using Shimadzu SPD-20A Prominence UV-Visible detector. The retention time of Levetiracetam was found to be 3.030 minutes. Linearity was established for Levetiracetam in the range of 10-50 µg/ml with correlation coefficient 0.9998. The LOD and the LOQ for Levetiracetam found to be 0.468 μg/ml and 1.421 μg/ml respectively. The amount of Levetiracetam present in the formulation was found to be 99.56 %. None of the excipients interfered with the analyte of interest. Considering all the results of validation parameters simplicity of the method and the cost effectiveness of the overall procedure, it is possible to conclude that the developed method can be suitable for the regular quality control determination of Levetiracetam in bulk as well as pharmaceutical dosage form.
Placenta percreta is a serious pregnancy condition that occurs when blood vessels and other parts of the placenta grow the deeply into the uterine wall. Placenta percreta is a rare but a life-threatening condition. Control of massive haemorrhage is the first priority; however, the patient's desire for future fertility has to be taken into consideration. Here we present a case where we had to do a quick subtotal hysterectomy because of torrential bleed due to placenta percreta with severe abdominal pain.
Thyroid gland is said to be one of the largest gland in our body. The hormones secreted by thyroid gland are namely T3 (liothyronine) and T4 (levothyroxine). The abnormalities (either increase or decrease) in these hormone levels may leads to various complications. The increased level of thyroid hormones in the body is called hyperthyroidism, whereas decreased levels of thyroid hormones in the body is called hypothyroidism or underactive thyroid. The major complications of hyperthyroidism are Graves' disease, Thyroiditis, Thyroid nodule etc., and major complications of hypothyroidism are Goiter, Heart problems, Mental health issues, Infertility, Myxedema, Birth defects etc.
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