Isolation of Anticancer Bioactive and In Vitro Evaluation of Antioxidant and Anticancer Activity of Cynodon dactylon (L). Pers

O, Sai Koushik; P, Srinivasa Babu

doi:10.21767/2172-0479.100023

Cited by 2 publications

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“…It is a potent medicinal herb in Ayurveda, Homoeopathy and Unani systems of medicine to cure different ailments [28]. In the modern context, the plant has different biological activities that were proved by efficient scholars in terms of anti-hyperglycemic [29], anti-diabetic [30], hepatoprotective [31], antihyperlipedemic [32], anti-inflammatory [33], anthelmintic [34], antimicrobial [35], antiarthritic [27] and antioxidant activity [36].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antimicrobial studies of bio silica nanoparticles prepared from Cynodon dactylon L.: a green approach

2018

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The present study reports on a green approach method for synthesis of silica nanoparticles (SiNPs) from Cynodon dactylon. These SiNPs were characterized by using ultraviolet-visible (UV-Vis) spectrophotometer, Fouriertransform infrared (FT-IR), dynamic light scattering (DLS) and Zeta, X-ray diffractometer (XRD), scanning electron microscope (SEM), transmission electron microscopy (TEM) and evaluated its growth inhibitory efficacy against different microorganisms. These SiNPs showed a colour change pattern upon synthesis and indicated a broad peak at 350 nm when analysed by UV-Vis spectrophotometer. FT-IR analysis revealed the presence of Si content, and the appearance of phytochemicals such as primary amines of proteins, phenols were mainly responsible for capping and stabilization of SiNPs. DLS and Zeta potential studies revealed average size of 62.1 nm and −23.3 mV zeta potential value of nanoparticles. An XRD study showed a broad peak at 22 • of 2θ value and confirmed that the nanoparticles were amorphous in nature with 60 nm average size of particles. Higher magnification studies with SEM and TEM analysis revealed that the particles were poly-dispersed, spherical in shape and have the size range from 7 to 80 nm without any agglomeration among the particles. Energy dispersive X-ray analysis showed a 52.84 weight percentage of silica content in the sample, which indicates towering purity of the sample. The obtained nanoparticles were tested for growth inhibitory activity on different microbial pathogens, resulting in potential inhibitory activity. This study concluded that the plant C. dactylon was an excellent and reliable green source for production of potential bio antimicrobial SiNPs.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antimicrobial studies of bio silica nanoparticles prepared from Cynodon dactylon L.: a green approach

2018

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In Silico Analysis of Phytochemicals From Various Plant Sources as Drug Candidates Against Life-Threatening Diseases

Jamkhedkar,

P. Nair,

R. Hirode

et al. 2023

IND. DRU.

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Epigenetic changes and glycation play a significant role in the progression of life-threatening diseases like diabetes, cancer, cardiovascular diseases (CVDs), neurodegenarative diseases (ND) and others. Exploring natural sources for overall therapeutic effect can be a beneficial approach for treating these life threatening diseases. The phytocemicals apigenin, aegeline, marmelosin, kaempferol, pyrrolemarumine 4”-O-alpha-L-rhamnopyranoside and garcinol from Durva, Bael, Custard apple, Moringa and Kokum were evaluated for their therapeutic value using in silico techniques. These phytochemicals and target structures (molecules from diseases pathologies from KEGG database), were obtained from PubChem and PDB, respectively. The docking studies, pharmaceutical parameters and toxicity studies were done using Swiss Dock, Swiss ADME for and Pro Tox II. The above phytochemicals have shown optimal lipophilicity, insaturation, flexibility and solubility. Molecular weight was less than 500 Da and LD50 values for each of these was above 400 mg kg-1. Amongst all phytochemicals, garcinol was found to be ideal for dermal drugs.

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Isolation of Anticancer Bioactive and In Vitro Evaluation of Antioxidant and Anticancer Activity of Cynodon dactylon (L). Pers

Cited by 2 publications

References 0 publications

Synthesis, characterization and antimicrobial studies of bio silica nanoparticles prepared from Cynodon dactylon L.: a green approach

Synthesis, characterization and antimicrobial studies of bio silica nanoparticles prepared from Cynodon dactylon L.: a green approach

In Silico Analysis of Phytochemicals From Various Plant Sources as Drug Candidates Against Life-Threatening Diseases

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