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To determine raised serum hsCRP levels, an established risk marker in stroke patients and also to study the co relation between raised serum uric acid and hsCRP levels in ischemic and hemorrhagic stroke. MATERIALS AND METHODS: This was a cross sectional study of 200 patients presenting with a history of focal neurological deficit of acute onset in the form of hemiparesis, hemiplegia having evidence of presence of ischemic or hemorrhagic infarct in CT scan of brain. In all patients hsCRP levels were measured within 48hours of presentation. RESULTS: Most of the patients (65%) were in the age group of more than 50 years. Left-sided hemiparesis with altered sensorium and UMN facial palsy was the most common presenting symptom. hsCRP levels were found to be increased in hemorrhagic stroke patients than with ischemic stroke, this difference was found to be statistically significant (p < 0.001). CONCLUSION: From this study we concluded that hsCRP level is increased in cases of stroke-ischemic as well as hemorrhagic, but more in hemorrhagic stroke suggesting an inflammatory response in acute stroke. Furthermore, the increased levels correlated with larger bleed and infarct size, severe neurological deficit and worse outcome.

Acromegaly is a rare disease characterised by chronic excess of Growth Hormone (GH) levels. Insulin signalling is impaired, gluconeogenesis is excess and peripheral insulin resistance is increased in acromegaly causing hyperglycaemia and diabetes. Diabetic Ketoacidosis (DKA) is a rare but known complication of diabetes in acromegaly. Most cases of acromegaly come into light due to the classical soft tissue changes in the face and extremities. A high index of suspicion is required to diagnose this condition in early stage. Here, a case of 22-years-old male presented with DKA and on investigation was found to have acromegaly due to a GH secreting pituitary macroadenoma. This management and subsequent follow-up of the case along with review of literature is also done. Such a presentation of acromegaly was rare but rewarding.

Purpose:We hypothesised that the difference in stroke rates observed in the ENDURANCE trial between HVAD and Heartmate II could be attributed to the difference in outflow graft diameters. Cerebral blood flow (CBF) patterns in the neck vessels was compared between 1. Normal pulsatile blood flow 2. A continuous flow pump (CFP) with a 10 mm outflow graft 3. CFP with a 14 mm outflow graft Methods: CT scan of a patient was converted into a 3D geometric model using Image Segmentation and Registration tool kit and a mesh for fluid structure interaction was prepared with four noded shell elements for the aortic wall and a tetrahedral fluid element. The complete human arterial tree model was built in Simulink .A CFP output of 5.8 Ltr/min and completely closed aortic valve condition was considered in the computational fluid dynamics analysis and the flow in the cerebral vessels was a DERIVED parameter and NOT given as an input. we studied CBF in