Objective: The objective of our study was to find out whether vitamin E and vitamins C levels in saliva can be used as a marker for cancer.
Material and Methods: This study was carried out in the dental OPD of Saraswathi Institute of Medical Sciences, Hapur, U.P. The saliva was collected from all the subjects. Results were compared with age, sex and matched with controls. Total 20 people were selected in which 10 normal subjects and 10 oral pre cancerous patients. Saliva was estimated for lipid peroxidation (malondialdehyde MDA), Vitamin E and C levels respectively.
Results: Our results indicated significant increase in lipid peroxidation (MDA) in oral precancerous stages but there was decrease in vitamin E and C levels. This suggests that there is an increase oxidative stress in oral precancerous lesion and may further increase in cancerous stages.
Conclusion: Free radical induced lipid peroxidation causes a loss of cell homeostasis by modifying the structure and functions of cell membrane. Their chief dangers come from damage they can do when they react with important cellular components such as DNA or the cell membrane. To prevent free radical damage body has a defense system of anti oxidants which are involved in the prevention of cellular damage – the common pathway for cancer ageing and a variety of diseases.
Preservation of alveolar bone is the main aim of conventional tooth-retained overdenture. In the past when patients reported for a denture with teeth that were badly broken down with periodontal involvement or due to large carious lesions, those teeth were extracted that could have been retained under more favourable conditions. Retention of the roots of one or more teeth for overdenture offers the patient a lot of advantages like better stability, proprioception, support among a few. The following case report focuses on the merits of using selectively retained roots and abutments to minimize alveolar ridge resorption below the complete dentures.
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