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A new series of N-aryl-4-oxo-1,4-dihydro-pyridazine-3-carboxylic acids has been synthesized by condensation of aryldiazonium with 4-hydroxy-6-methyl-2-pyrone. Some of these compounds exhibited in-vitro cytotoxic activity with moderate to excellent growth inhibition against the murine P815 mastocytoma cell line. Compound 5b showed an important cytotoxic activity against cell line P815 (IC(50 )= 0.40 microg/mL).

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A series of novel indazole–pyrone hybrids are synthesized and tested in vitro against both Leishmania donovani axenic and intramacrophage amastigotes.

Novel pyridazine derivatives are synthesized and tested for their cytotoxic activity on the P815 cell line. Compound (IIId) is identified as the most potent derivative. -(MOJAHIDI, S.; RAKIB*, E. M.; SEKKAK, H.; ABOURICHA, S.; BENCHAT, N.; MOUSSE, H. A.; ZYAD, A.; Arch.

The reaction of 3-allylrhodanine with 2-arylidene-4-methyl-5-oxopyrazolidinium ylides proceeded unexpectedly to the formation of novel 3-allyl-5-(arylidene)-2-thioxothiazolidin-4-ones 6a-k in good yields. All structures have been formulated on the basis of their spectral (IR, NMR, MS) data and elemental analyses. In addition, the structure of compound 6a was confirmed by means of X-ray crystallographic analysis.

In the title compound, C14H13NOS2, the atoms of the allyl group are disordered over two sets of sites, with an occupancy ratio of 0.559 (10):0.441 (10). The rhodanine ring makes a dihedral angle of 5.51 (12)° with the mean plane through the p-tolyl group. There are no specific inter­molecular inter­actions in the crystal packing.

Some new N-substituted pyridazinones and triazolo [4,3-b]pyridazinones were synthesized, respectively, by simple alkylation and 1,3-dipolar cycloaddition of pyridazin-3-one with nitrile imines. e regioselectivity of the reactions was ascertained by 1 H, 13 C NMR spectroscopy and X-ray diffraction of the synthesized compounds.