Winery pomace (from red and white grapes) was extracted under various conditions using different solvents. The antioxidant activity of solvent extracts was investigated by DPPH radical scavenging method. Ethanol extract exhibited the highest antioxidant activity compared to the other solvent (BuOH, EtOAc, Me 2 Cl 2 and pet.ether). There was a correlation between antioxidant activity and total phenol content. HPLC analysis of the extracts showed that gallic and cinnamic acid was the major phenolic compounds in winery pomace. Various phenolic compounds such as catechin, rutin, rosmarinic, chlorogenic, caffeic, vanillic, coumaric acids were also identified.
The adverse effect of cypermethrin on the liver and kidney of weanling female rats and the protective effect of ethanolic extract of grape pomace were investigated in the present study. Weanling female rats were given cypermethrin oral at a dose of 25 mg kg−1 body weight for 28 consecutive days. An additional two Cyp-trated groups received extract at a dose of 100 and 200 mg kg−1 body weight, respectively, throughout the experimental duration. Three groups more served as extract and control groups. Administration of Cyp resulted in a significant increase in serum marker enzymes, for example, aminotransferases (AST and ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT), and increases the level of urea nitrogen and creatinine. In contrast, Cyp caused significant decrease in levels of total protein and albumin and caused histopathological alterations in liver and kidneys of female rats. Coadministration of the extract to Cyp-treated female rats restored most of these biochemical parameters to within normal levels especially at high dose of extract. However, extract administration to Cyp-treated rats resulted in overall improvement in liver and kidney damage. This study demonstrated the adverse biohistological effects of Cyp on the liver and kidney of weanling female rats. The grape pomace extract administration prevented the toxic effect of Cyp on the above serum parameters. The present study concludes that grape pomace extract has significant antioxidant and hepatorenal protective activity.
Interest in the biological role of bioactive compounds present in medicinal herbs has increased over the last years. Of
particular interest are plants that have an anti-Alzheimer activities. Several plants can be useful for Alzheimer (AD)
management. Such as these which have anti-inflammatory activity, acetylcholinesterase (AChE) inhibitory action, antiapoptotic,
slow the aggregation of amyloid peptide and antioxidant activities. Grape seed extract (GSE) is a complex
mixture of several compounds, mostly represented by polyphenols and flavonoids. Their consumption is safe and is
recognized to exert several health benefits. GS flavonoids have been associated with the reduced risk of chronic diseases,
we present some findings on the potential benefits of GSE for the treatment of AD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.