Protective Effect of Ethanolic Extract of Grape Pomace against the Adverse Effects of Cypermethrin on Weanling Female Rats

Abstract

The adverse effect of cypermethrin on the liver and kidney of weanling female rats and the protective effect of ethanolic extract of grape pomace were investigated in the present study. Weanling female rats were given cypermethrin oral at a dose of 25 mg kg−1 body weight for 28 consecutive days. An additional two Cyp-trated groups received extract at a dose of 100 and 200 mg kg−1 body weight, respectively, throughout the experimental duration. Three groups more served as extract and control groups. Administration of Cyp resulted in a significant increase in serum marker enzymes, for example, aminotransferases (AST and ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT), and increases the level of urea nitrogen and creatinine. In contrast, Cyp caused significant decrease in levels of total protein and albumin and caused histopathological alterations in liver and kidneys of female rats. Coadministration of the extract to Cyp-treated female rats restored most of these biochemical parameters to within normal levels especially at high dose of extract. However, extract administration to Cyp-treated rats resulted in overall improvement in liver and kidney damage. This study demonstrated the adverse biohistological effects of Cyp on the liver and kidney of weanling female rats. The grape pomace extract administration prevented the toxic effect of Cyp on the above serum parameters. The present study concludes that grape pomace extract has significant antioxidant and hepatorenal protective activity.

Citrus limon and Paradisi Fruit Peel Hydroethanolic Extracts Prevent the Progress of Complete Freund’s Adjuvant-Induced Arthritis in Male Wistar Rats

“…was chosen according to (Tag et al, 2014) while that of C. paradisi peel hydroethanolic extract (100mg/kg b.w.) was chosen according to Mossa et al (Gupta et al, 2011;Mossa et al, 2015).…”

The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?

“…Neurotoxicity, hepatotoxicity, reproductive disturbances, and cancerogenesis belong to the negative effects exerted on organisms [ 6 , 8 , 15 , 71 ]. Moreover, chemicals of lipophilic character can be accumulated in membranes [ 9 ]. Enhanced generation of ROS was proved involved into their harmful influence [ 6 , 9 , 71 ].…”

“…Moreover, chemicals of lipophilic character can be accumulated in membranes [ 9 ]. Enhanced generation of ROS was proved involved into their harmful influence [ 6 , 9 , 71 ]. Plant origin materials were revealed to show protective properties not only by strengthening the antioxidant barrier but also by reversing histopathological changes.…”

“…Plant origin materials were revealed to show protective properties not only by strengthening the antioxidant barrier but also by reversing histopathological changes. A wide range of different materials was studied, including simple extracts [ 2 , 6 , 7 ] as well as commercial products [ 9 , 15 ]. The saponins from Tribulus terrestris , which were reported to possess antiaging action, were found to exert protective effects against rotenone-induced parkinsonism [ 15 ].…”

“…Despite the efforts aiming at alleviating and preventing this phenomenon, it still belongs to the most important problems to be solved by the mankind. The application of plant protection products has made another contribution to environmental contamination [ 6 – 9 ]. As it is not possible to improve the situation immediately, many people, i.e., industrial workers or farmers are still exposed to harmful substances like heavy metals [ 4 , 10 – 12 ], organic chemicals (e.g., CCl 4 ) [ 13 , 14 ], or pesticides and plant growth regulators [ 8 , 15 ].…”