This paper aims to identify an optimum bone fracture stabilizer. For this purpose, three design variables including the ratio of the screw diameter to the plate width at three levels, the ratio of the plate thickness to the plate width at three levels, and the diameter of the bone at two levels were selected for analysis. Eighteen 3D verified finite element models were developed to examine the effects of these parameters on the weight, maximum displacement and maximum von Mises stress of the fixation structure. Considering the relations between the inputs and outputs using multivariate regression, a genetic algorithm was used to find the optimal choices. Results showed that the diameter of the bone and the amount of load applied on it did not have a significant effect on the normalized stresses on the structures. Furthermore, in all ratio of the plate thickness to the plate width, as the ratio of the screw diameter to the plate width increased, the amount of stress on the structure decreased. But, by further increasing the ratio of the screw diameter to the plate width, the amount of stress on the structure increased. On the other hand, by increasing the value of the ratio of the plate thickness to the plate width, the maximum amount of stress on the structure decreased. Finally, optimal solutions in terms of the weight and the maximum amount of stress on the structure were presented.
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