The zona pellucida (ZP) is the spherical layer that surrounds the mammalian oocyte. The physical hardness of this layer plays a crucial role in fertilization and is largely unknown because of the lack of appropriate measuring and modelling methods. The aim of this study is to measure the biomechanical properties of the ZP of human/mouse ovum and to test the hypothesis that Young's modulus of the ZP varies with fertilization. Young's moduli of ZP are determined before and after fertilization by using the micropipette aspiration technique, coupled with theoretical models of the oocyte as an elastic incompressible half-space (half-space model), an elastic compressible bilayer (layered model) or an elastic compressible shell (shell model). Comparison of the models shows that incorporation of the layered geometry of the ovum and the compressibility of the ZP in the layered and shell models may provide a means of more accurately characterizing ZP elasticity. Evaluation of results shows that although the results of the models are different, all confirm that the hardening of ZP will increase following fertilization. As can be seen, different choices of models and experimental parameters can affect the interpretation of experimental data and lead to differing mechanical properties.

In this biomechanical study, there was no mechanical difference in the overall properties between a doubled and tripled tendon graft. Significant cyclic elongation occurred in the third limb of the tripled tendon in comparison with the doubled portioned. Further work is needed to determine whether these mechanical findings translate to clinical practice. Caution should be used when tripling hamstring grafts. In particular, tripling small grafts provides no biomechanical advantage immediately and possibly long term, thus potentially increasing the risk of failure.

Ultrasonic Testing (UT) is one of the well-known Non-Destructive Techniques (NDT) of spot-weld inspection in the advanced industries, especially in automotive industry. However, the relationship between the UT results and strength of the spot-welded joints subjected to various loading conditions is unknown. The main purpose of this research is to present an integrated search system as a new approach for assessment of tensile strength and fatigue behavior of the spot-welded joints. To this end, Resistance Spot Weld (RSW) specimens of three-sheets were made of different types of low carbon steel. Afterward, the ultrasonic tests were carried out and the pulse-echo data of each sample were extracted utilizing Image Processing Technique (IPT). Several experiments (tensile and axial fatigue tests) were performed to study the mechanical properties of RSW joints of multiple sheets. The novel approach of the present research is to provide a new methodology for static strength and fatigue life assessment of three-sheets RSW joints based on the UT results by utilizing Artificial Neural Network (ANN) simulation. Next, Genetic Algorithm (GA) was used to optimize the structure of ANN. This approach helps to decrease the number of tests and the cost of performing destructive tests with appropriate reliability.

Mechanical properties and manufacturing processes of Glass Fiber/Polypropylene (GF/PP) composites for application of flexible internal long bone fracture fixation plates have been investigated. PP/Short Chopped Glass Fiber (PPSCGF), PP/Long Glass Fiber (PPLGF) and PP/Long Glass Fiber Yarn (PPLGFY) were used in fabrication of the fixation plates. The PPSCGF and PPLGF plates were made by the heat-compressing process and Three-dimensional (3D) printing method was used to make the PPLGFY ones. The values of Young’s modulus, tensile strength, flexural modulus and strength, and impact strength of the PPSCGF in the fiber longitudinal direction were found to be [Formula: see text]GPa, [Formula: see text]MPa, [Formula: see text]GPa, [Formula: see text]MPa and [Formula: see text]kJ/m2, respectively. Where, these values for the PPLGF were to [Formula: see text]GPa, [Formula: see text]MPa, [Formula: see text]GPa, [Formula: see text]MPa, and [Formula: see text]kJ/m2 and for the PPLGFY were to [Formula: see text]GPa, [Formula: see text]MPa, [Formula: see text]GPa, [Formula: see text]MPa and [Formula: see text]kJ/m2. These have been found to be in close agreement with the human bone properties. Furthermore, the strength and modulus values of the plates were reasonable to be used as a bone implant applicable for bone fracture reconstructions. Hence, the study concluded that the GF/PP composites are useful for load-bearing during daily activities and would be recommended as a choice in orthopedic fixation plate applications. It will help the researchers for development of new fixation designs and the clinicians for better patient’s therapy in future.

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This paper, describes the biomedical testing of an Anterior Cruciate Ligament (ACL) reconstruction using an interference screw fixation on the bovine and porcine tissues. The harvesting procedure, experimental setup, mechanical testing, and evaluation of the tendon graft interference screw fixation are all presented throughout this study. A guideline has also been introduced to evaluate the basic mechanical properties of the bone components and the tendon graft.

The goal of this study is to investigate the effects of tendon and cannulated drill bit diameter on the strength of the bone and site hold tendon inside (BASHTI) fixation technique for an anterior cruciate ligament (ACL) reconstruction. Bovine digital tendons and Sawbones blocks were used to mimic the ACL reconstruction. Mechanical strength of the specimens was measured using a cyclic loading continued by a single cycle pullout load until failure to simulate the real postsurgical loading conditions. Finally, failure modes of specimens and ultimate failure load were recorded. The maximum possible tendon surface strain (i.e., tendon compression [TC]) for tendon diameters of 6, 7, 8, and 9 mm were 0.73, 0.8, 0.7, and 0.65, respectively. Eighty per cent of the specimens with tendon diameter of 6 mm and 20% of specimens with tendon diameter of 7 mm failed on the torn tendon. All samples with larger tendon diameters (i.e., 8 and 9 mm) failed on the fixation slippage. The maximum fixation strength according to the most suitable core bones for 6, 7, 8, and 9 mm tendons were 148 ± 47 N (core 9.5 mm), 258 ± 66 N (core 9.5 mm), 386 ± 128 N (core 8.5 mm), and 348 ± 146 N (core 8.5 mm), respectively. The mode of tendon failure was significantly influenced by the tendon diameter. Also, an increase in TC raised the fixation strength for all tendon diameters; however, tendon over compression decreased the fixation strength for the 8 mm tendon group. Finally, an empirical equation was proposed to predict BASHTI fixation strength.

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