Summary
Background : Crohn's disease is a chronic inflammatory condition affecting the gastrointestinal tract. Polyunsaturated omega‐3 fatty acids given orally may reduce the secretion of proinflammatory cytokines and hereby downregulate the inflammatory process.
Aim : To assess the effects of enteral fatty acids, in the form of Impact Powder (Novartis, Switzerland), as adjuvant therapy to corticosteroid treatment on the proinflammatory and anti‐inflammatory cytokine profiles in patients with active Crohn's disease.
Methods : The proinflammatory and anti‐inflammatory cytokines were measured in plasma from 31 patients with active Crohn's disease. Patients were randomized for oral intake of omega‐3 fatty acid (3‐Impact Powder) or omega‐6 fatty acids (6‐Impact Powder). Clinical and biochemical markers of inflammation were studied at baseline and after 5 and 9 weeks.
Results : Within the 3‐Impact Powder group, no significant changes in concentrations of interleukin‐6, interferon‐γ, monocyte chemoattractant protein‐1, interleukin‐2, interleukin‐5 and interleukin‐10, whereas a significant differences in concentration of interleukin‐1β and interleukin‐4 were observed during therapy. Within the 6‐Impact Powder group a significant changes in concentrations of interleukin‐1β, interleukin‐6, interferon‐γ, monocyte chemoattractant protein‐1, interleukin‐2, interleukin‐4, interleukin‐5 and interleukin‐10 were observed.
Conclusions : The 3‐Impact Powder showed immunomodulatory properties and might inhibit an increase of proinflammatory cytokines in contrast to the 6‐Impact Powder.
There was no difference between 3-IP and 6-IP as adjuvant enteral nutrition on the GH/IGF-I axis. The changes observed in the GH/IGF-I axis are in line with previously published studies and may be explained by corticosteroid treatment; however, we cannot exclude an additional effect of omega3-/omega6 FA as adjuvant enteral nutrition.
The hydrophilic, salt-soluble (SS) form of acetylcholinesterase (AChE) from bovine brain caudate nucleus exists mainly as a tetramer sedimenting at 10 .3S
Using crossed affinoimmunoelectrophoresis with free concanavalin A the glycandependent microheterogeneity of the immunoregulatory glycoprotein orosomucoid was examined in serum from 30 healthy individuals, 28 patients with benign chronic inflammation and 56 patients with cancer of various types and stages and before and after surgery. We found significant differences in glycan structure between the different patient groups. Thus the patients with the acute phase reaction of surgery differed from patients with chronic inflammation, and patients with testicular cancer differed from patients with colorectal cancer in having a greater proportion of biantennary glycan orosomucoid. Surgery was found to result in a temporary change in the relative proportions of the three microheterogeneity types of orosomucoid, lasting about one week.
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