Background: Hypertension and its associated disorders are major health concerns during pregnancy. Antihypertensive therapy prescribes, when blood pressure is >140/90 mm of Hg, to minimize elevated blood pressure. The present study aimed to assess the efficacy of nifedipine and methyldopa in the antihypertensive treatment of mild and severe pregnancy induced hypertension (PIH).Methods: A total one hundred Patients attending antenatal clinic of the department between 26-37 weeks of gestation suffering from PIH were recruited. Participants were divided in to two groups i.e. group-I consists of 50 patients medicated with oral methyldopa and group-II consists of 50 patients treated with Nifedipine 10mg.Results: Methyldopa reduced systolic blood pressure (SBP) from 162±19.6 to 140.3±10.01 and diastolic blood pressure (DBP) from 99.6±8.8 to 96.17±6.4. Nifedipine reduced SBP from 99.6±8.8 to 96.17±6.4 and DBP from 99.2± 7.4 to 93.45±12.3. Response to methyldopa and nifedipine was almost similar in mild PIH but in severe PIH, 65.5% of patients required additional drug atenolol for adequate control of PIH.Conclusions: Methyldopa and nifedipine are effective drugs for lowering blood pressure when given orally, Methyldopa was found to have a higher incidence of Intra uterine growth restriction while nifedipine was found to have an increased incidence of perinatal mortality.
Background: Low dose aspirin administration can reduce vasoconstriction and decreases thrombosis of the vessels related to placenta, thereby increases blood flow and protects against to pregnancy related complication like preeclampsia, IUGR or FGR. This study was undertaken to assess the efficacy of low dose aspirin (75 mg/day) on foetal and maternal outcome in preeclampsia patients.Methods: A total 100 preeclampsia patients were elected and were divided in to two groups i.e. control group includes age and parity matched preeclampsia cases under regular conventional treatment without aspirin administration and cases group receiving conventional treatment with aspirin 75 mg/ day after breakfast from recruitment upto one week before pregnancy.Results: There was a significant decrease in caesarean sections in cases (22%) and control groups (30%). Blood pressure, proteinuria was significantly reduced and platelets count was increased at time of presentation to after delivery in cases and controls. There was a less intra uterine deaths (8% in cases and 14% in controls) and neonatal deaths (2% in cases and 6% in controls) in cases than in controls. Neonatal haemorrhage was not accounted in both groups.Conclusions: Beginning of low dose aspirin administration in the early second trimester of pregnancy may reduce incidence of adverse health outcomes like IUGR, preeclampsia and preterm birth.
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